This book illustrates the intimate relationship between alveolar macrophages and Mycobacterium tuberculosis (M.tb.), and the former’s role in both innate and adaptive immunity against M.tb. It explores a novel approach to designing a new tuberculosis vaccine.
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Epidemiology of tuberculosis immunology.- Host pathogen specificity in tuberculosis.- Genetic determinants of susceptibility to mycobacterial infections.- Evolution of mycobacterium tuberculosis.- Mycobacterium tuberculosis genes involved in regulation of host cell death.- Dying to live: how the death modality of the infected macrophage affects immunity to tuberculosis.- Cytokines in the balance of protection and pathology during mycobactyerial infections.- Antigen-specific CD8+ T cells and protective immunity to tuberculosis.- Foxp3+ regulatory T cells in tuberculosis.- CD1a, CD1b, and CD1c in immunity against mycobacteria.- CD1d and natural killer T cells in immunity to mycobacterium tuberculosis.- The role of B cells and humoral immunity in mycobacterium tuberculosis infection.- Looking within the zebrafish to understand the tuberculosis granuloma.- Immunization strategies against pulmonary tuberculosis: Considerations of T cell geography.
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