Antibodies: Structure, Synthesis, Function, and Immunologic Intervention in Disease - Softcover

Softcover

ISBN 10: 1461318742 ISBN 13: 9781461318743

Publisher: Springer, 2014

Synopsis

Section I. Structures of Antibodies and the Combining Site.- The Three Dimensional Structure of Immunoglobulin G and Its Relationship to the Expression of Biological Functions.- New Concepts in Antibody Structure.- Nature of the Antibody Combining Site.- Section II. B Cell Development, Function, Repertoire and Activation.- B Cell Development in Mammals.- Control of ? and ? Gene Expression in B Lymphocyte Development.- Functional Maturation of B Cell Repertoire Expression.- Receptor Cross-Linkage Stimulates B Cell Activation.- Section III. Antibody Idiotypes, Anti-Idiotypes, and Network Regulation.- Induction of Antibodies to Pseudorabies Virus by Immunization with Anti-Idiotypic Antibodies.- Network and Regulation of the Idiotypic Repertoire.- Anti-Hapten Idiotype Models in Studies of Aging and Idiotype Networks.- Section IV. Immunologic Intervention With Anti-Idiotype Antibodies.- Antibodies to Acetylcholine, Adenosine and Glucocorticoid Receptors by an Auto-Anti-Idiotypic Route.- Idiotypic Interactions in the Treatment of Human Diseases.- Regulation of Autoimmune Diseases.- Section V. Immunologic Intervention with Monoclonal Antibodies.- Transfectomas Provide Antibodies with Novel Structures and Functions.- The Use of Ricin A Chain-Containing Immunotoxins to Kill Neoplastic B Cells.- Monoclonal Antibodies and Immunoconjugates as Anti-Cancer Agents.- Section VI. Overview and Comments.- Overview and Comments.- Contributors.

Edition details

• Publisher: Springer
• Publication date: 2014
• Language: English
• ISBN 10: 1461318742
• ISBN 13: 9781461318743
• Binding: Paperback
• Number of pages: 228
• Editor: Szentivanyi A, Maurer Paul H, Janicki Bernard W