Immunogenicity of Biopharmaceuticals: VIII (Biotechnology: Pharmaceutical Aspects, VIII) - Softcover

 
9781441926081: Immunogenicity of Biopharmaceuticals: VIII (Biotechnology: Pharmaceutical Aspects, VIII)
Softcover
ISBN 10: 1441926089 ISBN 13: 9781441926081
Publisher: Springer, 2010

Synopsis

A particular issue for biopharmaceuticals that has not been addressed comprehensively in any book, is the potential of an immune response to the biopharmaceutical product. That is, the human body marks the drug as a foreign body, and develops antibodies against the drug. These antibodies may be relatively harmless, but may also cross-react with the endogenous compound, causing autoimmunogenicity. Recent adverse experiences in Europe with Janssen-Ortho’s blockbuster product Eprex has increased the attention towards potential immunogenicity of biopharmaceuticals, above all from the regulatory agencies.

This book is intended to give a broad overview of the current state-of-the-art regarding the immune response to biopharmaceuticals. The chapters range from an overview of the immune system and factors that may trigger the immune system, via detection of antibodies and clinical implications, to various case examples and the regulatory view on immunogenicity.

"synopsis" may belong to another edition of this title.

Publisher
Springer
Publication date
2010
Language
English
ISBN 10 
1441926089
ISBN 13 
9781441926081
Binding
Paperback
Number of pages
278
Editor
Weert Marco, Møller Eva Horn

Other Popular Editions of the Same Title

9780387758404: Immunogenicity of Biopharmaceuticals: VIII (Biotechnology: Pharmaceutical Aspects, VIII)

Featured Edition

ISBN 10:  0387758402 ISBN 13:  9780387758404
Publisher: Springer, 2008
Hardcover