Synopsis
Casting Light on Neural Function: A Subjective History.- Fluorescent Sensors of Membrane Potential that Are Genetically Encoded.- The Influence of Astrocyte Activation on Hemodynamic Signals for Functional Brain Imaging.- Somatosensory: Imaging Tactile Perception.- How Images of Objects Are Represented in Macaque Inferotemporal Cortex.- Optical Imaging of Short-Term Working Memory in Prefrontal Cortex of the Macaque Monkey.- Intraoperative Optical Imaging of Human Cortex.- Using Optical Imaging to Investigate Functional Cortical Activity in Human Infants.- In Vivo Dynamics of the Visual Cortex Measured with Voltage Sensitive Dyes.- Fast Optical Neurophysiology.- Two-Photon Laser Scanning Microscopy as a Tool to Study Cortical Vasodynamics Under Normal and Ischemic Conditions.
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Review
“This is an excellent textbook of optical imaging techniques exploring cerebral cortical physiology using fMRI, OCT, and voltage-sensitive dyes. ... The book is well suited for neurophysiology students, fellows, and researchers. ... I highly recommend this book for all neurophysiology investigators.” (Joseph J. Grenier, Amazon.com, April, 2015)
“This volume is a good overview of the many uses of optical imaging to explore brain function. A wide range of methodologies discussed, and the techniques address research questions at different ‘levels of organization’ ... . It is therefore likely that individual scientists will find ... chapters directly relevant to their direct interests. ... Overall, this book contains very useful basic level reviews, other chapters cover systems-level and modality-specific ... techniques. The volume does cover an interesting range of optical methods.” (Robert V. Harrison, Canadian Journal of Neurological Sciences, Vol. 37 (5), September, 2010)From the Back Cover
The technology of detecting and interpreting patterns of reflected light has reached a remarkable degree of maturity that now permits high spatial and temporal resolution visualization at both the systems and cellular levels. There now exist several optical imaging methodologies, based on either hemodynamic changes in nervous tissue or neurally-induced light scattering changes, that can be used to measure ongoing activity in the brain. Imaging the Brain with Optical Methods presents the history of optical imaging and its use in the study of brain function, and the rapidly developing optical technologies and their applications that have recently developed. These
include intrinsic signal optical imaging, near-infrared optical imaging, fast optical imaging based on scattered light, optical imaging with voltage sensitive dyes, and 2 photon imaging of hemodynamic signals.
In total, this volume captures a profile of the current state of optical imaging methodologies and their contribution towards understanding the spatial and temporal organization of cerebral cortical function.
Imaging the Brain with Optical Methods will be highly valuable for researchers and clinicians interested in brain imaging methods and brain function, including advanced undergraduates, and doctoral students, neuroscientists, physicists, psychologists, bioengineers, neurologists, psychiatrists, and neurosurgeons.
About the author:
Dr. Anna W. Roe is a professor of psychology and radiology at Vanderbilt University. She has developed optical methods for studying brain function and specializes in how our brain builds real vs. illusory percepts of the world.
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