Integration/Interaction of Oncologic Growth: 15 (Cancer Growth and Progression) - Softcover

Softcover

ISBN 10: 140203413X ISBN 13: 9781402034138

Publisher: Springer-Verlag New York Inc., 2005

Synopsis

The present multi-volume Book Series, CANCER GROWTH AND PROGRESSION, encompasses the widest possible framework of cutting edge research in the field of neoplastic pathology and other integrated fields. Normal and pathologic growth is one of the most intensively studied yet challenging areas in pathology. Thus the individual volumes in this series focus on the topics of highest scientific interest for basic and clinical researchers, pathologists, medical and surgical oncologists and allied multidisciplinary teams interested in the study of these aspects of neoplastic growth, progression and inhibition. The range of topics covered is extensive, including but not limited to autonomous growth characteristics of malignancy, phenomena of progression of malignant growth involving the various body systems, and recent advances being made in successful neoplastic inhibition and control. Cell function may be described as producing progression or regression, often found as alternating features in tumors or as variations between normal tissues and tumors. The source of regression in normal melanin producing cells may not be the same as in melanomas. These functions of living matter persist in all phyla of eumetazoans vascular plants as well as in particular species of fungi. However, homo sapiens are the eumetazoan species, which interest us the most. Normal growth processes cannot be entirely understood in all its diversity until we have a thorough knowledge of what constitutes normal growth in various organisms.

About this title

Synopsis

This book addresses the interactions and interrelationships between tumor and host that modulate progression and metastasis. A unique aspect of the book is that it highlights the tumor/host interactions as new targets for therapeutic intervention to control cancer. One promising approach is to target the host rather than the tumor itself, and several authors examine the potential for this novel tactic to oppress the manipulative cancer cell. The book examines the tumor and host relationship from multiple viewpoints: cellular and molecular events that occur during tumor-host cell interactions that control differentiation, cell proliferation, angiogenesis and vasculogenic mimicry, migration, apoptosis, invasion, metastasis. Other topics include the role of the immune response and chemokines/chemokine receptors, and the role of the brain and nutrients in tumor and host survival. Drug resistance limits cancer therapy, and the book emphasizes numerous novel and future therapeutic directions to sensitize drug resistant cells and other approaches that target the tumor and host microenvironment.

This book will be of interest to cancer researchers who are interested in understanding metastasis, tumor and host interaction and interrelationships, and who have an interest in cancer control through development of novel targeting agents that impact these processes.

Edition details

• Publisher: Springer-Verlag New York Inc.
• Publication date: 2005
• Language: English
• ISBN 10: 140203413X
• ISBN 13: 9781402034138
• Binding: Paperback
• Number of pages: 454
• Editor: Meadows Gary G.