Enantiomer Separation: Fundamentals and Practical Methods (Subcellular Biochemistry) - Hardcover

Hardcover

ISBN 10: 1402023367 ISBN 13: 9781402023361

Publisher: Springer, 2005

Synopsis

Many important pharmaceutical drugs, chemicals for the organic synthesis of chiral compounds, electronic elements such as liquid crystals, and polymeric materials are chiral (enantiomeric). The development of new practical methods for the preparation of enantiomerically pure substances is thus vital. Enantiomer Separation is written by several experts working in modern enantiomer separation chemistry who understand the needs of the many scientific and engineering chemists who need a cost-efficient supply of optically active materials of high quality. This book contains the following modern practical methods of enantiomer separation: Practical methods of enantiomer separation are important both in the research laboratory and in industry, especially in the pharmaceutical, fine chemical and electronic industries. Chemists and engineers, as well as students who are working in the field of chiral compounds in universities, institute and industry, will find this book an invaluable resource.

About this title

Review

From the reviews:

"This is an authoritative account of ... the methods applicable to the large-scale separation of enantiomers, edited by a leading authority on inclusion complexation using crystalline chiral host molecules ... . the basic science of enantiomer separation is well documented. The text is clearly printed ... . this book does provide accurate and detailed information on recently emerging techniques, and should be very useful to development chemists and scale-up scientists requiring access to single enantiomers on the multi-gram scale." (D. R. Taylor, Chromatographia, Vol. 63 (5-6), 2006)

"This book covers enantiomer separation, with an emphasis on separation by chiral inclusion complexes and crystallization, biological methods ... as well as preparative liquid and gas chromatographic methods. ... this book succeeds in covering the practical methods for separating enantiomers on a preparative scale. ... it can be recommended as a resource for those working in the field of enantiomer separation, especially enzymatic resolutions, the practical aspects of crystallization, and preparative scale chromatography techniques." (Thomas K. Green, Journal of the American Chemical society, Vol. 128 (5), 2006)

Synopsis

"Enantiomer Separation" is written by several experts working in modern enantiomer separation chemistry who understand the needs of the many scientific and engineering chemists who need a cost-efficient supply of optically active materials of high quality. This book contains the following modern practical methods of enantiomer separation: inclusion complexation of a racemic compound with a chiral host compound, which gives chiral host-chiral guest inclusion compounds, from which the chiral guest can be obtained. When this separation is combined with distillation technique, for example, enantiomer separation can be accomplished by fractional distillation in the presence of a chiral host compound. This is a modern and "green" procedure of enantiomer separation. These separation methods are described in several chapters of the book.Biological separation methods and 'green' methods are covered in two chapters. Enantiomer separation by chromatography on a column containing chiral solid phase is one of the most up-to-date and well known "green" methods of enantiomer separation.

Two experts in chromatography have contributed to provide two very important chapters on this method of separation. Practical methods of enantiomer separation are important both in the research laboratory and in industry, especially in the pharmaceutical, fine chemical and electronic industries. Chemists and engineers, as well as students who are working in the field of chiral compounds in universities, institute and industry, will find this book an invaluable resource.

Edition details

• Publisher: Springer
• Publication date: 2005
• Language: English
• ISBN 10: 1402023367
• ISBN 13: 9781402023361
• Binding: Hardcover
• Number of pages: 340
• Editor: Toda Fumio