The Croonian lectures on some points in the pathology of rheumatism, gout and diabetes; delivered at the Royal College of Physicians, London, March 30, April 1, 6, 1886 - Softcover
Synopsis
This historic book may have numerous typos and missing text. Purchasers can download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1887 Excerpt: ...hydantoic acid Salkowski Berichte, Tin. S. 115) first stated that in the urine of dogs it appeared only in small quantity after the administration of sarcosine, whereas Bauman and v. Mering in their experiments on the human subject showed that after administering as much as 25 grammes of sarcosine, methyl hydantoic acid was entirely absent from the urine, and that Schultzen in his experiments could not have had this substance to deal with. At the same time they discovered a probable source of error in his experiments, viz. that in the presence of sarcosine Liebig's test for urea fails. They discovered also, as Salkowski also did, that a portion of the sarcosine appeared unchanged in the urine. In later communications Salkowski confirmed the view of Bauman and von Mering that, after the administration of sarcosine there is no appearance whatever of methyl hydantoic acid in the urine." "There appeared to be very little left then from Schultzen's experiments. One point only still remained for investigation. As the uramido-acids are so easily converted into their anhydrides, and as this is specially so in the case of methyl hydantoic acid and its conversion into methyl hydantoin, this latter substance might possibly exist in the urine after the internal administration of sarcosine. Salkowski has given great care and attention to this point, without however arriving at any definite proof." "This then was the state of the question, when Professor Bauman informed me that methyl hydantoin reduces sulphate of copper in an alkaline solution and asked me to make some fresh experiments with sarcosine founded upon this reaction." Schiffer then describes the experiments which he performed to demonstrate the existence of methyl hydantoin in the ur...
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