This historic book may have numerous typos and missing text. Purchasers can download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1917. Excerpt: ... which agree in that the intercellular substance is fibrous and large in amount. Examples of connective tissue have been encountered in the study of cross-sections of various organs. For more careful study, connective tissue may be prepared as follows: From a preserved frog cut out a small piece of the white fibrous connective tissue that fastens the skin to the body, spread it on a slide in a drop of water, and cover it with a cover glass. Under high power observe the numerous fibers, which are usually unbranched and of a characteristic wavy appearance. Irregularly distributed among the fibers are the connective tissue corpuscles or cells; these have conspicuous granular nuclei and vary considerably in form and in the appearance of the cytoplasm. Sketch a small portion of connective tissue. XL The Skeleton. The skeleton, which forms the hard internal parts of the frog, is composed partly of cartilage and partly of bone. In the early stages of development the skeleton consists entirely of cartilage; in the adult this primary cartilaginous skeleton is replaced to a considerable extent by bone. Bones formed thus by replacement of cartilage are called cartilage bones. By far the greater portion of the skeleton of the frog is made up of cartilage bones. Cartilage may also be calcified (i. e., become hardened by a deposit of calcareous material) without taking on the histological character of true bone. Bones may also be developed in places where there is no preexisting cartilage and are then, in distinction from cartilage bones, called membrane bones. Membrane bones are formed as ossifications in the cutis or deeper layer of the skin; in many fishes they retain this primitive position, but in the frog and in most higher vertebrates they sink beneath the skin a...
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