Items related to On carbohydrate metabolism; (a course of advanced lectures...
On carbohydrate metabolism; (a course of advanced lectures in physiology delivered at the University of London, May, 1905) with an appendix on the ... fundamental principles and the treatment o - Softcover
Synopsis
This historic book may have numerous typos and missing text. Purchasers can download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1906 Excerpt: ...afford confirmatory evidence in relation to the view that has just been expressed. Volume XXIX, 1903, of the Journal of Physiology contains a communication by Pavy, Brodie, and Siau on the "Mechanism of Phloridzin Glycosuria," in which the point in question is dealt with. The conclusion we SOUliCE OF SUGAR IN PHLORIDZIN GLYCOSURIA. 69 arrived at from the experimental work performed was that the sugar eliminated is derived from the katabolic action of the renal cells on a constituent of the blood containing sugar in a locked-up state. This idea was previously mentioned at a meeting of the Pathological Society in April, 1902. Loewi1 has expressed a similar idea and has even gone the length of suggesting that the sugar, which is ordinarily looked upon as being in a free form in the blood, is in reality in a loosely combined state when the blood is circulating in the body. We did not commit ourselves to agreeing with this proposition, although otherwise we stood in accord with him. It is clearly established that the glycosuria produced by phloridzin is not due to hyperglycaemia, and it hence follows that there must be something in the blood to yield the sugar. The first effect of the phloridzin is to sweep away the glycogen th&t is present in the different parts of the body. If this passed through the circulatory system as free sugar, there ought to be hyperglycaemia in proportion to the glycosuria, which there certainly is not. This being the case, the only conclusion that can be drawn is that the katabolised glycogen (sugar) enters into side chain or loose combination with a constituent (proteid) of the blood, and is thus conveyed to the kidney, where it is set free and eliminated. For a great number of years cases of diabetes have from time to ...
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