Synopsis
This Element reviews key aspects of RAS biochemistry that are directly relevant to understanding the newly available RAS inhibitors.
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Therapeutic Targeting of RAS Mutant Cancers (Elements in Molecular Oncology)
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Cambridge University Press, 2022
ISBN 10: 1009073648
ISBN 13: 9781009073646
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Therapeutic Targeting of RAS Mutant Cancers (Paperback)
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Cambridge University Press, Cambridge, 2022
ISBN 10: 1009073648
ISBN 13: 9781009073646
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Paperback. Condition: new. Paperback. The KRAS oncogene is believed to be the most common single nucleotide variant oncogene in human cancer. Historically, efforts to target KRAS and the other RAS GTPases have struggled. More recently, efforts have focused on identifying and exploiting features unique to specific oncogenic mutations. This has led to the first FDA approval for a RAS targeted therapy. This new agent is a covalent inhibitor that reacts with the cysteine residue created by a codon 12 glycine to cysteine (G12C) mutation within KRAS. Mutant-specific strategies may also exist for other KRAS single nucleotide variants, and recent studies provide examples and mechanisms. The KRAS oncogene is believed to be the most common single nucleotide variant oncogene in human cancer. Historically, efforts to target KRAS and the other RAS GTPases have struggled. More recently, efforts have focused on identifying and exploiting features unique to specific oncogenic mutations. This item is printed on demand. Shipping may be from multiple locations in the US or from the UK, depending on stock availability. Seller Inventory # 9781009073646
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Therapeutic Targeting of RAS Mutant Cancers
Published by
Cambridge University Press, 2022
ISBN 10: 1009073648
ISBN 13: 9781009073646
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Therapeutic Targeting of RAS Mutant Cancers
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Cambridge University Press, 2022
ISBN 10: 1009073648
ISBN 13: 9781009073646
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Therapeutic Targeting of RAS Mutant Cancers (Elements in Molecular Oncology)
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Cambridge University Press, 2022
ISBN 10: 1009073648
ISBN 13: 9781009073646
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Therapeutic Targeting of RAS Mutant Cancers (Elements in Molecular Oncology)
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Cambridge University Press, 2022
ISBN 10: 1009073648
ISBN 13: 9781009073646
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Therapeutic Targeting of RAS Mutant Cancers (Elements in Molecular Oncology)
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Cambridge University Press, 2022
ISBN 10: 1009073648
ISBN 13: 9781009073646
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Therapeutic Targeting of RAS Mutant Cancers (Elements in Molecular Oncology)
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Cambridge University Press, 2022
ISBN 10: 1009073648
ISBN 13: 9781009073646
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Therapeutic Targeting of RAS Mutant Cancers (Elements in Molecular Oncology)
Published by
Cambridge University Press, 2022
ISBN 10: 1009073648
ISBN 13: 9781009073646
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Therapeutic Targeting of RAS Mutant Cancers (Elements in Molecular Oncology)
Published by
Cambridge University Press, 2022
ISBN 10: 1009073648
ISBN 13: 9781009073646
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