Tuberculosis: The Microbe Host Interface - Hardcover

Schlesinger, Larry S.; DesJardin, Lucy

Hardcover

ISBN 10: 0954523210 ISBN 13: 9780954523213

Publisher: Taylor & Francis, 2003

Synopsis

M. tuberculosis remains one of the most successful human pathogens known. The causative agent of tuberculosis, it also has a unique ability to persist for years in the infected, apparently healthy host. This dormant organism can be reactivated years, even decades later to cause tuberculosis. Knowledge regarding the interaction of M. tuberculosis with the host is fundamental to understanding the pathogenesis, leading eventually to the development of strategies for the prevention and control of infection and disease.
By integrating genetic, microbiologic, immunologic, and cell biologic approaches to elucidate pathogenesis, penetrating new insights into the interaction of M. tuberculosis with the host have emerged. This book reviews the most important state-of-the-art approaches currently used to study microbe-host interactions and highlights emerging methodologies. Strategies to analyze the following topics are included: mycobacterial entry, growth, and gene expression in macrophages; analysis of post-phagocytic events; analysis of signaling in infected macrophage; the acquired immune response; newer animal- and non animal-models systems; latency; and the epidemiology of M. tuberculosis infections.

About this title

About the Author

Larry S. Schlesinger (The Ohio State University, USA) (Author), Lucy DesJardin (University of Iowa, USA) (Author)

Edition details

• Publisher: Taylor & Francis
• Publication date: 2003
• Language: English
• ISBN 10: 0954523210
• ISBN 13: 9780954523213
• Binding: Hardcover
• Edition number: 1
• Number of pages: 292