This comprehensive overview includes all that is presently known about imidazoline receptors, a newly recognised binding site for clonidine and other clinically important antihypertensive agents. The diversity of imidazoline receptors and their complexity and possible relationships to the functions of a range of organs are discussed as is identification of novel endogenous ligands. The pharmacologic significance of these receptors in the potential treatment of hypertension, sickle cell disease, and other disorders is also reported.
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