Matrix Metalloproteinase Inhibitors in Cancer Therapy (Cancer Drug Discovery and Development) - Hardcover

Hardcover

ISBN 10: 0896036685 ISBN 13: 9780896036680

Publisher: Humana Press Inc., 2000

Synopsis

Cutting-edge investigators review the current status of the entire field, from the biology of MMPs through the current clinical studies.

About this title

From the Back Cover

The association of matrix metalloproteinases (MMPs)-enzymes that disrupt the body's normal repair functions-with several diseases, including growing and invasive tumors, holds the tantalizing promise that their inhibiton might have therapeutic value. In Matrix Metalloproteinase Inhibitors in Cancer Therapy, cutting-edge investigators review the current status of the entire field, from the biology of MMPs through the current clinical studies. The authors include many leading scientists from pharmaceutical companies who present all the latest concepts and results on the preferred design strategies for MMP inhibitors, their molecular mechanisms, and their substrates. In addition, they fully describe their company's research effort on specific MMP inhibitors, detailing vanguard design strategies, their in vitro activity, the outcome of animal model studies and, where available, their toxicology, safety, and efficacy in human clinical trials. Comprehensive and state-of-the-art, Matrix Metalloproteinase Inhibitors offers basic and clinical investigators alike a richly informative summary of all the latest research on these powerful new drugs, and their high promise as emerging cancer therapeutics.

Edition details

• Publisher: Humana Press Inc.
• Publication date: 2000
• Language: English
• ISBN 10: 0896036685
• ISBN 13: 9780896036680
• Binding: Hardcover
• Number of pages: 275
• Editor: Clendeninn Neil J., Appelt Krzysztof