Items related to Molecular Biology of B-Cell and T-Cell Development...

Molecular Biology of B-Cell and T-Cell Development (Contemporary Immunology) - Hardcover

 
9780896035362: Molecular Biology of B-Cell and T-Cell Development (Contemporary Immunology)

Synopsis

This cutting-edge review of the current status of research on the early development of lymphocytes emphasizes molecular mechanisms controlling lineage commitment and selection. The reviews explore cellular and molecular aspects of the microenvironment in regulating lymphoid development, discuss ligands and receptors that mediate interactions between progenitor and cells comprising the stromal microenvironment, and demonstrate which are the triggering receptors, signaling pathways, and the developmental checkpoints controlling correct development of B- and T-cells. There is also a comparison of the vital roles of transcription factor combinations in establishing cell identity in the erythroid, myeloid, B, and T lineages. By juxtaposing the insights and approaches normally confined to either immunology or hematology, this important book will help spark the growth of new research initiatives at the intersection of these two fields.

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Review

". . . can be unequivocally recommended to people involved in the study of lymphocytes and lymphoma research."-Annals of Oncology

"...This volume presents an integrated and comprehensive account of cutting edge advances in understanding B and T lymphocyte development, and a deeper understanding of the actual cellular and molecular processes that control cell fates....this important new book will help spark the growth of new research initiatives at the intersection of these two fields, claiming center ground as essential reading in the field."-Anticancer Research

Synopsis

This cutting-edge review of the current status of research on the early development of lymphocytes emphasizes molecular mechanisms controlling lineage commitment and selection. The reviews explore cellular and molecular aspects of the microenvironment in regulating lymphoid development, discuss ligands and receptors that mediate interactions between progenitor and cells comprising the stromal microenvironment, and demonstrate which are the triggering receptors, signaling pathways, and the developmental checkpoints controlling correct development of B- and T-cells. There is also a comparison of the vital roles of transcription factor combinations in establishing cell identity in the erythroid, myeloid, B, and T lineages. By juxtaposing the insights and approaches normally confined to either "immunology" or "hematology," this important book will help spark the growth of new research initiatives at the intersection of these two fields.

"About this title" may belong to another edition of this title.