Voltammetric Methods in Brain Systems: 27 (Neuromethods, 27) - Hardcover

Hardcover

ISBN 10: 0896033120 ISBN 13: 9780896033122

Publisher: Humana, 1995

Synopsis

Efforts to measure neurotransmitters and related s- cies in living brain tissue by faradic electrochemistry began in earnest in the early 1970s. During the ensuing years, s- eral monographs and various symposia on the subject have appeared. The present volume of Neuromethods, Voltammetric Methods in Brain Systems, can be considered different from previous offerings in several respects. The methodology of in vivo electrochemistry has now reached a stable level of maturity. It is no longer necessary to convince interested re- ers that the techniques can measure, with specified degrees of reliability, certain neurotransmitters and metabolites in the extracellular fluid space. Moreover, the basic approaches of electroanalytical measurements are more widely appre- ated by neuroscientists and one need not explain in tutorial fashion the details of oxidative electrochemistry. Nevert- less, in keeping with the nature of the Neurumethods series, this is a "how to" volume and readers will find ample detail on the preparation of electrodes, practical experimental details, and the interpretation of results. But the emphasis is strongly on the application of voltammetric methods. The first two chapters deal with fundamentals inherent in employing in vivo electrochemical measures. The first - ticle offers an authoritative account of our understanding of the surface states of carbon and carbon fiber electrodes. It provides a rationale for the various pretreatments that have allowed the "tuning" of electrode properties to obtain sen- tivity and fast response times.

About this title

From the Back Cover

Voltammetric Methods in Brain Systems offers neuroscientists at all levels of expertise a combination of theory and practical how-to instructions for using in vivo and on-line neurotransmitter measurements in their experimental brain systems. Coverage includes the entire spectrum of applications for in situ, brain slices, transplant media, cell cultures, and single cells. Emphasis is on fast measurements that reveal release-reuptake information on transmitter systems. How-to information ranges from ample detail on the preparation of electrodes, to practical experimental details, to the interpretation of results. Written by many of the world's leading experts - often those whose laboratories have spearheaded work in the area - Voltammetric Methods in Brain Systems provides insightful views on all the best approaches and experimental techniques, with sufficient introductory material and practical detail to satisfy both newcomers and experienced researchers.

Edition details

• Publisher: Humana
• Publication date: 1995
• Language: English
• ISBN 10: 0896033120
• ISBN 13: 9780896033122
• Binding: Hardcover
• Number of pages: 365
• Editor: Boulton Alan A., Baker Glen B., Adams Ralph