Despite the success of earlier Neuromethads volumes, I was initially reluctant to edit a further volume because my own - search is concerned with nonneural tissues. I changed my mind for two simple reasons. First, though the sheer diversity of ext- cellular signal molecules is staggering, still more impressive is the remarkably small number of transmembrane signaling processes they recruit- their receptors either have integral ion channels or enzyme activities, or else they catalytically activate G proteins. Likewise, when we look to the final intracellular t- gets of these signaling pathways, they are stucturally diverse, but again there are common themes: the response may either be the gating of an ion channel, or else the phosphorylation of a target protein. Such conservation of signaling mechanisms is both impressive and convenient, and provides my justification for asking authors with interests in diverse tissues to contribute their methodological expertise to this volume. Second, I think it would be difficult to overestimate the extent to which our understanding of intracellular signaling has been transformed by new and improved methodology. Thus, simple methods for measuring inositol phosphates have revealed the profound and widespread importance of the ph- phoinositide pathways, the techniques of contemporary - lecular biology have provided unrivaled opportunities to relate structure and function, and the complex spatial and t- poral characteristics of intracellular signaling pathways were barely imaginable before the introduction of fluorescent indi- tors and single cell-imaging technology.
"synopsis" may belong to another edition of this title.
An extensive review of current knowledge of intracellular information processing....comprehensive....[Offers] a valuable extension to 'classical' neurobiology and provides new tools in neurochemistry.-Journal of Chemical Neuroanatomy
This timely new volume in the highly acclaimed "Neuromethods" series focuses on major new advances in understanding the signaling mechanisms employed by neural tissues. Chapters, contributed by experts in the field, provide thorough, up-to-date coverage of a variety of topics and techniques, including: single-cell imaging technology; phosphorylation of target proteins; analysis of phosphoinositides and inositol phosphates; inositol trisphosphate and intracellular calcium; guanine nucleotide-binding proteins; ion channel gating; measurement of intracellular calcium with fluorescent calcium indicators; protein kinase C; synthetic analogs of intracellular messengers; cyclic nucleotides; caged intracellular messengers; intracellular regulators and components of the exocytotic pathway; and, intracellular messengers in vertebrate and invertebrate photoreceptors. "Neuromethods 20 - Intracellular Messengers" is an essential resource for neurobiologiests at all levels of research.
"About this title" may belong to another edition of this title.
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Gebunden. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Despite the success of earlier Neuromethads volumes, I was initially reluctant to edit a further volume because my own - search is concerned with nonneural tissues. I changed my mind for two simple reasons. First, though the sheer diversity of ext- cellular. Seller Inventory # 5981990
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Condition: Sehr gut. Zustand: Sehr gut | Seiten: 604 | Sprache: Englisch | Produktart: Bücher | Despite the success of earlier Neuromethads volumes, I was initially reluctant to edit a further volume because my own - search is concerned with nonneural tissues. I changed my mind for two simple reasons. First, though the sheer diversity of ext- cellular signal molecules is staggering, still more impressive is the remarkably small number of transmembrane signaling processes they recruit- their receptors either have integral ion channels or enzyme activities, or else they catalytically activate G proteins. Likewise, when we look to the final intracellular t- gets of these signaling pathways, they are stucturally diverse, but again there are common themes: the response may either be the gating of an ion channel, or else the phosphorylation of a target protein. Such conservation of signaling mechanisms is both impressive and convenient, and provides my justification for asking authors with interests in diverse tissues to contribute their methodological expertise to this volume. Second, I think it would be difficult to overestimate the extent to which our understanding of intracellular signaling has been transformed by new and improved methodology. Thus, simple methods for measuring inositol phosphates have revealed the profound and widespread importance of the ph- phoinositide pathways, the techniques of contemporary - lecular biology have provided unrivaled opportunities to relate structure and function, and the complex spatial and t- poral characteristics of intracellular signaling pathways were barely imaginable before the introduction of fluorescent indi- tors and single cell-imaging technology. Seller Inventory # 3648235/202
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Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Despite the success of earlier Neuromethads volumes, I was initially reluctant to edit a further volume because my own - search is concerned with nonneural tissues. I changed my mind for two simple reasons. First, though the sheer diversity of ext- cellular signal molecules is staggering, still more impressive is the remarkably small number of transmembrane signaling processes they recruit- their receptors either have integral ion channels or enzyme activities, or else they catalytically activate G proteins. Likewise, when we look to the final intracellular t- gets of these signaling pathways, they are stucturally diverse, but again there are common themes: the response may either be the gating of an ion channel, or else the phosphorylation of a target protein. Such conservation of signaling mechanisms is both impressive and convenient, and provides my justification for asking authors with interests in diverse tissues to contribute their methodological expertise to this volume. Second, I think it would be difficult to overestimate the extent to which our understanding of intracellular signaling has been transformed by new and improved methodology. Thus, simple methods for measuring inositol phosphates have revealed the profound and widespread importance of the ph- phoinositide pathways, the techniques of contemporary - lecular biology have provided unrivaled opportunities to relate structure and function, and the complex spatial and t- poral characteristics of intracellular signaling pathways were barely imaginable before the introduction of fluorescent indi- tors and single cell-imaging technology. 604 pp. Englisch. Seller Inventory # 9780896032071
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Condition: New. Part of the "Neuromethods" series, this book focuses on advances in understanding the signaling mechanisms employed by neural tissues. It provides coverage of a variety of topics and techniques, such as: single-cell imaging technology; phosphorylation of target proteins; analysis of phosphoinositides and inositol phosphates; and, others. Series: Neuromethods. Num Pages: 580 pages, biography. BIC Classification: MFG; MJN; PSAN. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly; (UU) Undergraduate. Dimension: 235 x 155 x 38. Weight in Grams: 1052. . 1992. Hardback. . . . . Seller Inventory # V9780896032071
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Buch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Despite the success of earlier Neuromethads volumes, I was initially reluctant to edit a further volume because my own - search is concerned with nonneural tissues. I changed my mind for two simple reasons. First, though the sheer diversity of ext- cellular signal molecules is staggering, still more impressive is the remarkably small number of transmembrane signaling processes they recruit- their receptors either have integral ion channels or enzyme activities, or else they catalytically activate G proteins. Likewise, when we look to the final intracellular t- gets of these signaling pathways, they are stucturally diverse, but again there are common themes: the response may either be the gating of an ion channel, or else the phosphorylation of a target protein. Such conservation of signaling mechanisms is both impressive and convenient, and provides my justification for asking authors with interests in diverse tissues to contribute their methodological expertise to this volume. Second, I think it would be difficult to overestimate the extent to which our understanding of intracellular signaling has been transformed by new and improved methodology. Thus, simple methods for measuring inositol phosphates have revealed the profound and widespread importance of the ph- phoinositide pathways, the techniques of contemporary - lecular biology have provided unrivaled opportunities to relate structure and function, and the complex spatial and t- poral characteristics of intracellular signaling pathways were barely imaginable before the introduction of fluorescent indi- tors and single cell-imaging technology.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 604 pp. Englisch. Seller Inventory # 9780896032071
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Hardcover. Condition: New. Dust Jacket Condition: New. 1st Edition. Totowa, New Jersey: Humana Press (1992).New Hardcover, New DJ. Signature on the Flyleaf otherwise The book is perfect. 9.3"x6.3"x1.5". be4x. Seller Inventory # ABE-1517576561587