Essentials of Glycobiology - Hardcover

Ajit Varki

Hardcover

ISBN 10: 0879697709 ISBN 13: 9780879697709

Publisher: Cold Spring Harbor Press, 2008

Synopsis

The new edition of Essentials of Glycobiology covers the general principles and describes the structure and biosynthesis, diversity and function of glycans and their relevance to both normal physiologic processes and human disease. Several new chapters present significant advances that have occurred since the publication of the first edition. Three sections of note describe organismal diversity, advances in our understanding of disease states and related therapeutic applications, and the genomic view of Glycobiology. Glycomics , analogous to genomics and proteomics, is the systematic study of all glycan structures of a given cell type or organism, and paves the way for a more thorough understanding of the functions of these ubiquitous molecules. The first edition of Essentials of Glycobiology represented also a notable experiment in publishing, as it became one of the first electronic textbooks. And, now, in recognition of its wide audience and the changing ways in which researchers and students learn and access information, the new edition of Essentials will be made available online simultaneously with the print edition. This novel experiment is the result of the collaborative efforts of the Cold Spring Harbor Laboratory Press, the National Center for Biotechnology Information, and the Editors of the book. Written and edited by glycobiologists with experience in teaching and in research, this volume will be an invaluable resource, both for students and for established investigators in fields such as, developmental biology, cell biology, neuroscience, immunology, biochemistry etc., who require a complete yet concise introduction to this burgeoning field. Partial Contents (51 chapters in total): GENERAL PRINCIPLES 1. Historical Background and Overview A. Varki and N. Sharon 2. Structural Basis of Glycan Diversity C.R. Bertozzi and D. Rabuka 3. Cellular Organization of Glycosylation A. Varki, J.D. Esko, and K.J. Colley 4. Glycosylation Precursors H.H. Freeze and A.D. Elbein 5. Glycosyltransferases and Glycan-processing Enzymes J.M. Rini, J.D. Esko, and A. Varki 6. Biological Roles of Glycans A. Varki and J.B. Lowe 7. A Genomic View of Glycobiology B. Henrissat, A. Surolia, and P. Stanley STRUCTURE AND BIOSYNTHESIS 8. N-Glycans P. Stanley, H. Schachter, and N. Taniguchi 9. O-GalNAc Glycans I. Brockhausen, H. Schachter, and P. Stanley 10. Glycosphingolipids R.L. Schnaar, A. Suzuki, and P. Stanley 11. Glycosylphosphatidylinositol Anchors M.A.J. Ferguson, T. Kinoshita, and G.W. Hart 12. Other Classes of ER/Golgi-derived Glycans H.H. Freeze and R. Haltiwanger 13. Structures Common to Different Glycan Classes P. Stanley and R.D. Cummings 14. Sialic Acids A. Varki and R. Schauer 15. Hyaluronan V. Hascall and J.D. Esko 16. Proteoglycans and Sulfated Glycosaminoglycans J.D. Esko, K. Kimata, and U. Lindahl 17. Unique Forms of Nucleocytoplasmic Glycosylation G.W. Hart and C.M. West 18. The O-GlcNAc Modification G.W. Hart and Y. Akimoto ORGANISMAL DIVERSITY 19. Evolution of Glycan Diversity A. Varki, H.H. Freeze, and P. Gagneux 20. Eubacteria and Archaea J.D. Esko, T.L. Doering, and C.R.H. Raetz 21. Fungi R.D. Cummings and T.L. Doering 22. Viridiplantae M.E. Etzler and D. Mohnen 23. Nematoda R.D. Cummings and J.D. Esko 24. Arthropoda M. Tiemeyer, S.B. Selleck, and J.D. Esko 25. Deuterostomes H.H. Freeze, V.D. Vacquier, and J.D. Esko GLYCAN-BINDING PROTEINS 26. Discovery and Classification of Glycan-binding Proteins A. Varki, M.E. Etzler, R.D. Cummings, and J.D. Esko 27. Principles of Glycan Recognition R.D. Cummings and J.D. Esko 28. R-type Lectins R.D. Cummings and M.E. Etzler 29. L-type Lectins M.E. Etzler, A. Surolia, and R.D. Cummings 30. P-type Lectins A. Varki and S. Kornfeld

About this title

Review

The basic principles of glycobiology are clearly articulated in this volume, and the roles of complex carbohydrates in disease are an important read for all biomedical scientists. --Peter Agre, M.D., Nobel Laureate in Chemistry, 2003

Essentials of Glycobiology is a major resource for understanding these post-translational biochemical reactions that affect the function and fate of proteins produced by the genes that are profoundly changed by their added sugars. --Baruch S. Blumberg, Nobel Laureate in Medicine, 1976

The second edition of Essentials of Glycobiology, superbly printed and illustrated, develops in simple and absolutely precise terms the complicated intricacies of glycobiology. I would have killed to get this encyclopedic treatise 40 years ago when I was working my way through this field. --Edmond H. Fischer, Nobel Laureate in Medicine, 1992

Essentials of Glycobiology is a major resource for understanding these post-translational biochemical reactions that affect the function and fate of proteins produced by the genes that are profoundly changed by their added sugars. --Baruch S. Blumberg, Nobel Laureate in Medicine, 1976

The second edition of Essentials of Glycobiology, superbly printed and illustrated, develops in simple and absolutely precise terms the complicated intricacies of glycobiology. I would have killed to get this encyclopedic treatise 40 years ago when I was working my way through this field. --Edmond H. Fischer, Nobel Laureate in Medicine, 1992

Synopsis

The sugar chains of cells - known collectively as glycans - play a variety of roles in biological systems. One of the more rapidly growing fields in the natural sciences, Glycobiology is the study of these roles of glycans in the growth and development, function and survival of an organism. These findings, described in vivid detail in the text, have become increasingly significant in many areas of basic research as well as biomedicine and biotechnology.The new edition of "Essentials of Glycobiology" covers the general principles and describes the structure and biosynthesis, diversity and function of glycans and their relevance to both normal physiologic processes and human disease. Several new chapters present significant advances that have occurred since the publication of the first edition. Three sections of note describe organismal diversity, advances in our understanding of disease states and related therapeutic applications, and the genomic view of Glycobiology.

'Glycomics', analogous to genomics and proteomics, is the systematic study of all glycan structures of a given cell type or organism, and paves the way for a more thorough understanding of the functions of these ubiquitous molecules.The first edition of "Essentials of Glycobiology" represented also a notable experiment in publishing, as it became one of the first electronic textbooks. And, now, in recognition of its wide audience and the changing ways in which researchers and students learn and access information, the new edition of "Essentials" will be made available online simultaneously with the print edition. This novel experiment is the result of the collaborative efforts of the Cold Spring Harbor Laboratory Press, the National Center for Biotechnology Information, and the Editors of the book. Written and edited by glycobiologists with experience in teaching and in research, this volume will be an invaluable resource, both for students and for established investigators in fields such as, developmental biology, cell biology, neuroscience, immunology, biochemistry etc., who require a complete yet concise introduction to this burgeoning field.

Edition details

• Publisher: Cold Spring Harbor Press
• Publication date: 2008
• ISBN 10: 0879697709
• ISBN 13: 9780879697709
• Binding: Hardcover
• Language: English
• Edition number: 2
• Number of pages: 784
• Editor: Ajit Varki