The RNA World: Monograph 37 - Hardcover

Gesteland, Raymond F.; Cech, Thomas R.; Atkins, John F.

Hardcover

ISBN 10: 0879695617 ISBN 13: 9780879695613

Publisher: Cold Spring Harbor Laboratory Press,U.S., 1998

Synopsis

Revised, updated, and expanded since first appearing in 1993, this work offers the molecular biologist thorough treatment of both the hypothetical NRA World and the complexities of RNA structure and function found today. Containing 24 chapters, the volume addresses topics relating to the origins of RNA, including geophysical and geochemical constraints on molecular evolution, the genomic tag hypothesis, re-creating an RNA replicase, and introns. Building functional RNA is also covered, with contributions on the interactions that shape NRA structure, small ribozymes, the role of metal ions in RNA biochemistry, and ribonuclease P. Additionally, transition to the RNP world is covered, with contributions on RNA interaction with small ligands and peptides, Group I and II ribozymes as RNPs, splicing of precursors to mRNAs by the spliceosome, RNA editing, and telomerase. Includes color and b&w illustrations and five appendices providing relevant figures and diagrams. Annotation c. by Book News, Inc., Portland, Or.

About this title

Synopsis

As both an informational molecule and a catalyst, RNA may hold clues to the emergence of genetic self-replication and the origins of life. This revised and updated edition reviews the modern world of RNA and the light it sheds on a prebiotic era perhaps dominated by this versatile molecule.

Edition details

• Publisher: Cold Spring Harbor Laboratory Press,U.S.
• Publication date: 1998
• Language: English
• ISBN 10: 0879695617
• ISBN 13: 9780879695613
• Binding: Hardcover
• Edition number: 2
• Number of pages: 730