Fundamental Toxicology: Rsc - Hardcover

Hardcover

ISBN 10: 0854046143 ISBN 13: 9780854046140

Publisher: Royal Society of Chemistry, 2006

Synopsis

Fundamental Toxicology is a comprehensive review of toxicology. It is based on the highly successful 'Fundamental Toxicology for Chemists' and has been enriched and expanded.

About this title

From the Back Cover

This book is a core introductory text to the subject of toxicology and the use of toxicological information for risk assessment by chemists. Increasingly, chemists are being required by law to advise on the safe handling of chemicals. Few chemists, however, have been trained in toxicology, and the subject is often not covered in a chemistry degree curriculum. It is to address this problem that this book has been written. Fundamental Toxicology for Chemists contains a proposed curriculum for teaching toxicology to chemists, which gives a firm grounding in the basics. With this book as a guide, lecturers will be able to design courses that cover all their students needs. In addition, students in all areas of chemistry will find it invaluable. Fundamental Toxicology for Chemists offers a unique assessment of the subject specifically for chemists. It is both comprehensible and fully comprehensive, covering developing areas such as reproduction, behavioural and ecological toxicology. The book has been approved by the IUPAC (International Union of Pure and Applied Chemists) committees on toxicology and the teaching of chemistry. It has a comprehensive index and an extensive glossary of terms, and will have lasting value to all chemists as a reference, and a text book.

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Fundamental Toxicology

By John H. Duffus, Howard G. J. Worth

The Royal Society of Chemistry

Copyright © 2006 The Royal Society of Chemistry
All rights reserved.

ISBN: 978-0-85404-614-0

Contents

Chapter 1 Introduction to Toxicology John H. Duffus, 
Chapter 2 Introduction to Toxicodynamics Robert F.M. Herber, 
Chapter 3 Toxicokinetics Andrew G. Renwick, 
Chapter 4 Data Interpretation John S.L. Fowler, 
Chapter 5 Risk Assessment H. Paul A. Illing, 
Chapter 6 Risk Management H. Paul A. Illing, 
Chapter 7 Exposure and Monitoring Douglas M. Templeton, 
Chapter 8 Genetic Toxicology Douglas McGregor, 
Chapter 9 Carcinogenicity Douglas McGregor, 
Chapter 10 Introduction to Toxicogenomics Darrell Boverhof, Jeremy Burt and Timothy Zacharewski, 
Chapter 11 Reproductive Toxicity Frank M. Sullivan, 
Chapter 12 Immunology and Immunotoxicology Graeme Wild, 
Chapter 13 Skin Toxicology David A. McKay and Roger D. Aldridge, 
Chapter 14 Respiratory Toxicology Raymond Agius and Anil Adisesh, 
Chapter 15 Hepatotoxicity Alison L. Jones, 
Chapter 16 Nephrotoxicity Robert F.M. Herber, 
Chapter 17 Neurotoxicity John H. Duffus, 
Chapter 18 Behavioural Toxicology Gerhard Winneke, 
Chapter 19 Pathways and Behaviour of Chemicals in the Environment Monika Herrchen, 
Chapter 20 Ecotoxicity – Effects of Toxicants on Ecosystems Martin Wilkinson, 
Chapter 21 Radionuclides Milton V. Park, 
Chapter 22 Biocides and Pesticides Birger Heinzow and Helle Raun Andersen, 
Chapter 23 Toxicology in the Clinical Laboratory Robin A. Braithwaite, 
Chapter 24 Pharmaceutical Toxicology Robin A. Braithwaite, 
Chapter 25 Safe Handling of Chemicals Howard G.J. Worth, 
Appendix A: A Curriculum for Fundamental Toxicology, 
Appendix B: Glossary of Terms Used in Toxicology, 
Appendix C: Abbreviations and Acronyms Used in Toxicology, 
Appendix D: Abbreviations and Acronyms of Names of International Bodies and Legislation, 

CHAPTER 1

Introduction to Toxicology

JOHN H. DUFFUS

1.1 INTRODUCTION

Toxicology is the fundamental science of poisons. A poison is generally considered to be any substance that can cause severe injury or death as a result of a physicochemical interaction with living tissue. However, all substances are potential poisons since all of them can cause injury or death following excessive exposure. On the other hand, all chemicals can be used safely if exposure of people or susceptible organisms to chemicals is kept below defined tolerable limits, i.e. if handled with appropriate precautions. If no tolerable limit can be defined, zero exposure methods must be used.

Exposure is a function of the amount (or concentration) of the chemical involved, and the time and frequency of its interaction with people or other organisms at risk. For very highly toxic substances, the tolerable exposure may be close to zero. In deciding what constitutes a tolerable exposure, it is essential to have data relating exposure to the production of injury or adverse effect. A problem often arises in deciding what constitutes an injury or adverse effect.

An adverse effect is defined as an abnormal, undesirable or harmful change following exposure to the potentially toxic substance. The ultimate adverse effect is death but less severe adverse effects may include altered food consumption, altered body and organ weights, visible pathological changes or simply altered enzyme levels. A statistically significant change from the normal state of the person at risk is not necessarily an adv

Edition details

• Publisher: Royal Society of Chemistry
• Publication date: 2006
• Language: English
• ISBN 10: 0854046143
• ISBN 13: 9780854046140
• Binding: Hardcover
• Edition number: 2
• Number of pages: 26
• Editor: John H Duffus