Developmental Control of Globin Gene Expression (Progress in Clinical & Biological Research) - Hardcover

Hardcover

ISBN 10: 0845151010 ISBN 13: 9780845151013

Synopsis

This volume outlines the remarkable progress being made in research on the modulation of globin gene expression and hemoglobin switching. Outstanding coverage of the many diversified aspects of globin gene expression is presented, ranging from the cell biology of hematopoiesis to globin gene organization and developmental expression. Molecular analyses of globin gene expression and mutants are provided, as well as insights into globin gene expression from studies using heterokaryons, hybrids and transgenic mice. The volume also provides comprehensive reviews of Hb F and b-locus haplotypes, the modulation of fetal hemoglobin in adults, in vivo control of globin switching, and somatic gene therapy. Specific topics examined in the book include: regulation of human globin gene expression in human erythroid cells; stage-specific reprogramming of globin gene expression; developmental clocks and hemoglobin switching; transfer and expression of human genes in murine hematopoietic stem cells; structure of the gene of human IL-3.

About this edition

• ISBN 10: 0845151010
• ISBN 13: 9780845151013
• Binding: Hardcover