Cell Biology of Virus Entry Replication and Pathogenesis - Hardcover

9780845126899: Cell Biology of Virus Entry Replication and Pathogenesis

Hardcover

ISBN 10: 084512689X ISBN 13: 9780845126899

Publisher: Alan R. Liss, 1989

Discusses interactions between viruses and their host cells, with emphasis on use of viruses in basic studies in cell biology, virology, and immunology. Describes the architecture of viruses and viral antigens (including HIV), investigates virus entry and virus receptors, and reports on intracellular traffic of viral proteins. Also discusses emerging concepts in viral pathogenesis, including molecular pathogenesis of the slow infection "visna," MHC class 1 antigens and tumorigenesis, and the basis of "Sindbis" virus neurovirulence.

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Synopsis

A comprehensive analysis of the interactions between viruses and their host cells, with emphasis on the viruses as tools for basic studies in cell biology, virology, and immunology, is presented in this book. The volume begins with a detailed review of the architecture of viruses and viral antigens, including an insightful discussion of the expression, isolation, and characterization of human immunodeficiency viruses. The next two sections examine virus receptors and virus entry, respectively, with topics ranging from the action of retrovirus receptors on human cells to the mechanisms of enveloped virus entry into host cells. Following this, the reader will find in-depth reports on the intracellular traffic of viral proteins, as well as the interaction of cytotoxic T-cells with virus-infected cells. The final section of the book focuses on new and emerging concepts in viral pathogenesis, including data on the molecular pathogenesis of the slow visna infection, MHC Class 1 antigens and tumorigenesis, and the basis of Sindbis virus neurovirulence. Other topics include: exocytic and endocytic membrane traffic, post-translational modification, receptor biology, membrane fusion, cell polarity, antiviral immune defenses, antigen presentation, cellular immune responses.

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