Items related to Carbohydrate Modifications in Antisense Research: No....
Synopsis
Reviews recent developments and progress in the carbohydrate-related chemistry of novel nucleic acid mimics and their applications in antisense therapeutics. Discusses the use of new chemical classes to rationally design and synthesize oligonucleotides. Explores several carbohydrate modifications of the oligonucleotide to stabilize against nuclease degradation and to enhance the binding affinity for a given target. Suggests future directions of carbohydrate-related modifications for antisense molecules.
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Review
"Highly recommended for those working in, or directly involved with antisense research, and who want to keep up with the latest developments in this emerging field."--European Journal of Organic Chemistry
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