Synopsis
Introducing the most recent advances in crystallography, nuclear magnetic resonance, molecular modeling techniques, and computational combinatorial chemistry, this unique, interdisciplinary reference explains the application of three-dimensional structural information in the design of pharmaceutical drugs. Furnishing authoritative analyses by world-renowned experts, Structure-Based Drug Design discusses protein structure-based design in optimizing HIV protease inhibitors and details the biochemical, genetic, and clinical data on HIV-1 reverse transcriptase presents recent results on the high-resolution three-dimensional structure of the catalytic core domain of HIV-1 integrase as a foundation for divergent combination therapy focuses on structure-based design strategies for uncovering receptor antagonists to treat inflammatory diseases demonstrates a systematic approach to the design of inhibitory compounds in cancer treatment reviews current knowledge on the Interleukin-1 (IL-1) system and progress in the development of IL-1 modulators describes the influence of structure-based methods in designing capsid-binding inhibitors for relief of the common cold and much more!
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Pandi Veerapandian
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Structure-Based Drug Design
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Taylor & Francis Inc Jul 1997, 1997
ISBN 10: 0824798694
ISBN 13: 9780824798697
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Buch. Condition: Neu. Neuware - Introducing the most recent advances in crystallography, nuclear magnetic resonance, molecular modeling techniques, and computational combinatorial chemistry, this unique, interdisciplinary reference explains the application of three-dimensional structural information in the design of pharmaceutical drugs. Furnishing authoritative analyses by world-renowned experts, 'Structure-Based Drug Design' discusses protein structure-based design in optimizing HIV protease inhibitors and details the biochemical, genetic, and clinical data on HIV-1 reverse transcriptase; presents recent results on the high-resolution three-dimensional structure of the catalytic core domain of HIV-1 integrase as a foundation for divergent combination therapy; focuses on structure-based design strategies for uncovering receptor antagonists to treat inflammatory diseases; demonstrates a systematic approach to the design of inhibitory compounds in cancer treatment; reviews current knowledge on the Interleukin-1 (IL-1) system and progress in the development of IL-1 modulators; describes the influence of structure-based methods in designing capsid-binding inhibitors for relief of the common cold and much more! Seller Inventory # 9780824798697