Synopsis
Because of the predominant role estrogens play in the development of breast cancer and the limited effectiveness of tamoxifen therapy, more selective therapeutics targeting estrogen signaling have been developed: selective estrogen receptor modulators (SERMs), selective estrogen receptor downregulators (SERDs), and a third generation of drugs that inhibit the aromatase required for estrogen biosyntheses. The authors examine clinical and translational research results from studies of these endocrine therapies and chemotherapies in pre- and postmenopausal women with early and advanced breast cancer. Advances in Endocrine Therapy of Breast Cancer provides guidance on promising new therapeutics and treatment combinations based on compelling clinical evidence.
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Synopsis
Estrogen is predominant in the development of breast cancer, and efforts are under way to develop effective therapies targeting estrogen signaling. The result of the July 2003 Gleneagles Conference, these papers and transcripts of panel discussions evaluate the clinical pharmacology of selective estrogen receptor modulators (SERMs), selective estro
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Endocrine Therapy for Breast Cancer (Basic and Clinical Oncology)
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CRC Press, 2004
ISBN 10: 0824722280
ISBN 13: 9780824722289
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Advances in Endocrine Therapy of Breast Cancer
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