Comparative Pharmacokinetics: Principles, Techniques and Applications - Hardcover

Riviere, Jim

Hardcover

ISBN 10: 0813829313 ISBN 13: 9780813829319

Publisher: Wiley–Blackwell, 1999

Synopsis

This text presents an overview of pharmacokinetics. It explains the scientific data and mathematical models of the discipline within the context of biological reality. It uses a complete model of the field, from facts and constructs to clinical manifestations. Written for students, researchers, and comparative medicine clinicians, the book explains and assesses both mechanistic, compartmental models, and the newer empirical noncompartmental models, considering strengths and weaknesses of each. The text also explains establishment of appropriate parameters and proper collection and linking of data. Cross-referenced information provides multiple opportunities for study form a variety of perspectives and ultimately aids decision making. The book concludes with application of techniques to common problems.

About this title

From the Back Cover

Comparative Pharmacokinetics: Principles, Techniques, and Applications presents a unique and highly practical overview of pharmacokinetics. This text explains the scientific data and mathematical models of the discipline within the context of “biological reality.” This offers readers a complete sourcebook for the field – from facts and constructs to clinical applications.

Written for students, researchers, and comparative medicine clinicians, the book thoroughly explains and assesses both mechanistic (compartmental and physiological-based) models as well as newer empirical (noncompartmental and population) models, considering strength and weaknesses of each. Comparative Pharmacokinetics presents approaches to data analysis and experimental design with an eye toward practical applications. At the same time, this easy-to- read book is understandable to the reader with minimal mathematical background.

Author Riviere demonstrates how pharmacokinetic concepts unify many topics in comparative medicine by first overviewing the basic processes of drug absorption and disposition, and then outlining how pharmacokinetic approaches can measure these. Riviere's experience as a researcher and teacher are put to use explaining models, including establishing suitable parameters, proper collection, and linking of data.

Cross-referenced information provides opportunity for examination from a variety of user perspectives, proving helpful in using pharmacokinetic information to make decisions. Current and timely, Comparative Pharmacokinetics will be an important reference tool for medical, veterinary, and pharmacy researchers and students

About the Author

Jim E. Riviere, D.V.M., Ph.D. is the Burroughs Wellcome Fund Distinguished Professor of Veterinary Pharmacology and Director, Center for Chemical Toxicology Research and Pharmacokinetics, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, N.C. .

Edition details

• Publisher: Wiley–Blackwell
• Publication date: 1999
• Language: English
• ISBN 10: 0813829313
• ISBN 13: 9780813829319
• Binding: Hardcover
• Number of pages: 338