Analysis of Human Genetic Linkage, revised edition - Hardcover

Ott

Hardcover

ISBN 10: 0801842573 ISBN 13: 9780801842573

Publisher: John Hopkins University Press, 1991

Synopsis

The first and still the only book of its kind, this volume offers a concise introduction to human genetic linkage analysis and gene mapping. Jurg Ott provides mathematical and statistical foundations of linkage analysis for researchers and practitioners, as well as practical comments on available computer programs and websites. Each chapter ends with a set of problems, whose solutions are found at the end of the book.

New to this edition is a chapter on complex traits, such as diabetes, some cancers, and psychiatric conditions. Also new is an overview of nonparametric approaches to linkage and association analysis. A chapter on two-locus inheritance introduces the reader to many of the intricate aspects of complex traits. Although the book's primary audience is in the field of genetics, physicians and others without sophisticated training in genetics can understand and apply the principles and techniques discussed.

About this title

Review

"Overall the book achieves an excellent compromise between presenting important conclusions and working out the details... Analysis of Human Genetic Linkage is a good book that has been made substantially better. It continues to be the standard reference for every linkage analyst's library and to provide an excellent introduction for the interested beginner with a background in the biological or mathematical sciences." -- American Journal of Human Genetics

Synopsis

According to the preface: "Linkage analysis is sometimes perceived as a matter of simply using the proper computer program. . . . Such claims are not usually made in other fields of research and should not be made here either." This text provides the necessary background. Each chapter ends with problems (solutions provided). Annotation copyright Bo

Edition details

• Publisher: John Hopkins University Press
• Publication date: 1991
• Language: English
• ISBN 10: 0801842573
• ISBN 13: 9780801842573
• Binding: Hardcover
• Edition number: 2
• Number of pages: 320