Radioiodination: Theory, Practice, and Biomedical Applications: 21 (Developments in Nuclear Medicine, 21) - Hardcover

Dewanjee, Mrinal K.

Hardcover

ISBN 10: 0792314913 ISBN 13: 9780792314912

Publisher: Springer, 1992

Synopsis

Among the readily available -emitting radionuclides, the nuclides of iodine have the greatest versatility in labeling both the hydrophilic and the lipophilic compounds that are used in biology and medicine. Biologically important micrmolecules, semimacromolecules, and macromolecules have been identified which, after iodination, almost maintain the same molecular configuration and similar biologic specificity as those of the parent molecules. The multiple techniques for iodination and the clinical use of iodinated products have made possible the present status of the development of diagnostic nuclear medicine. 125r, with a half-life of 60 days, has a crucial role in competitive protein-binding studies. 131r is useful for measuring thyroid uptake, for the diagnosis of thyroid carcinoma and metastasis, and for therapy. 1nr , with a reasonably shorter half-life, is almost ideal for thyroid workup and for a few useful labeled radiopharmaceutical. Although ~c is used more widely in diagnostic procedures, the radionuclides of iodine will always have a major role in biology and medicine. A considerable amount of information is scattered in the literature regarding the chemistry of radioiodination and the mechanism of tracer localization in cells and tissues. Labeled peptides, proteins, and antibodies are extensively used for protein turnover studies, receptor binding and tumor imaging studies, and radioimmunoassay. The general trend in the use of tracers in clinical nuclear medicine has been an evolution from 3H, 14C, 11C, and 13 to 125 , 131 and 123r to ~c and 111rn.

About this title

Synopsis

The radionuclides of iodine have the greatest versatility in labelling both hydrophilic and lipophilic compounds that are used in biology and medicine. The multiple techniques for iodination and the clinical use of iodinated products have made possible the present status of the development of diagnostic nuclear medicine. A considerable amount of information on this topic is scattered through the literature and the author has gathered this and presented it in an ordered and systematic fashion, covering the period to 1990. On the basis of his extensive experience in laboratories of nuclear physics, nuclear chemistry, and radiochemistry, Dewanjee has produced a masterly, and above all practical book, directed at the gamut of readers, from basic scientists to clinicians and from students to experienced investigators.Each chapter is carefully structured, beginning with definitions and progressing to more comprehensive presentations of the disciplines of chemistry, biochemistry, molecular biology, physiology and pharmacology.

The book is divided into six parts: Introduction; Preparation of Tracers; Localization of Tracers; Organ Imaging and Tracer Applications; Purification of Substrate, Quality Control of Tracers; and, Radiation Damage During Storage. A final part presents material for additional reading, being a supplement to the references that are cited at the end of each chapter. A clear and comprehensive index rounds off the work.

Edition details

• Publisher: Springer
• Publication date: 1992
• Language: English
• ISBN 10: 0792314913
• ISBN 13: 9780792314912
• Binding: Hardcover
• Number of pages: 644