Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury: Proceedings of the 1st International Conference October 11–14, 1989 Detroit, Michigan USA: 67 (Developments in Oncology, 67) - Hardcover

Hardcover

ISBN 10: 0792313038 ISBN 13: 9780792313038

Publisher: Springer, 1991

Synopsis

This volume contains the proceedings of the First International Conference on Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury held in Detroit, Michigan on October 11-14, 1989. The program consisted of 83 oral and 29 poster presentations, 74 of which are included in these proceedings. The major sponsors of the conference were the Armed Forces Radiobiology Research Institute, located in Bethesda, Maryland, the Radiation Oncology Research and Development Center of the Gershenson Radiation Oncology Center, Harper Hospital in Detroit, Michigan, and Schering AG of West Germany. Eighteen other organizations provided additional support. The conference was unique in its attempt to link the eicosanoid and lipid researchers in the radiobiology and cancer disciplines. The diverse roles that eicosanoids and other bioactive lipids play in these biological phenomena including the participation of lipid oxidation in conversion of procarcinogens, positive and negative modulation of tumor growth, immunomodulation, tissue injury, and yet protection and enhancement of cancer therapy, necessitated scientific interaction to sort out and understand these complex and sometimes contradictory observations. The success of this effort is reflected not only through these proceedings, but also through the decision to continue the conference series with a second meeting to be held in Berlin between September 17-21, 1991.

About this title

Review

' The paradoxical roles of eicosanoids (stimulation/inhibition of injury processes) are the primary subjects of the investigations reviewed in this book. It will be of great interest to both researchers and clinicians.' Annals of Oncology 3:10 1992

Synopsis

This volume contains the proceedings of the First International Conference on Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury held in Detroit, Michigan on October 11-14, 1989. The conference was unique in its forging of a link between the eicosanoid and lipid researchers in the disciplines of radiobiology and cancer. The diverse roles that eicosanoids and other bioactive lipids play in these biological phenomena, including the participation of lipid oxidation in conversion of procarcinogens, positive and negative modulation of tumor growth, immunomodulation, tissue injury, and yet protection and enhancement of cancer therapy, necessitated a scientific interaction to sort out and understand these complex and sometimes contradictory observations. The scope of this volume encompasses the complete range of eicosanoid studies in these two fields, beginning with discussions of improved means of detecting eicosanoids using radio-immunoassays, high performance liquid chromatography, and GC-mass spectrometry and including specialized assays of the enzyme system involved in the metabolism of the bioactive lipids.

Studies on the mechanistic basis of bioactive lipids in carcinogenesis and radiation injury have been conducted in vitro in biochemical assays and cell culture, culminating in observations in vivo, including applications in the treatment of cancer patients.

Edition details

• Publisher: Springer
• Publication date: 1991
• Language: English
• ISBN 10: 0792313038
• ISBN 13: 9780792313038
• Binding: Hardcover
• Number of pages: 543
• Editor: Honn Kenneth V., Marnett Lawrence J., Nigam Santosh, Walden Jr. Thomas