Cytotoxic Cells: Basic Mechanisms and Medical Applications - Hardcover

Hardcover

ISBN 10: 0781716039 ISBN 13: 9780781716031

Publisher: Lippincott Williams and Wilkins, 1999

Synopsis

This volume synthesizes recent groundbreaking advances in our knowledge of the molecular mechanisms, biological roles, and medical applications of cytotoxic lymphocytes. Leading investigators examine current concepts on the recognition of antigen by T-cell receptors; the molecules mediating target recognition by natural killer cells; the intracellular signalling cascades triggered by these molecules; and the effector molecules that damage target cells. The contributors present new insights into the roles of cytotoxic lymphocytes in vivo in immune regulation, autoimmunity, antiviral resistance, and tumor surveillance. Several chapters explore potential medical applications of cytotoxic lymphocytes, including vaccines, tumor therapy, and treatment of HIV infection.

About this title

Synopsis

Serving as a single source overview and reference in the field, this volume contains 31 contributions, arranged in the following sections: historical overview; target cell recognition; effector cell signaling pathways; cytotoxic effector molecules; cytotoxic lymphocytes in vivo ; CTL generation and memory; and medical applications of cytotoxic lymp

Edition details

• Publisher: Lippincott Williams and Wilkins
• Publication date: 1999
• Language: English
• ISBN 10: 0781716039
• ISBN 13: 9780781716031
• Binding: Hardcover
• Number of pages: 472
• Editor: Sitovsky Michail V., Henkart Pierre A.