Neuronal Mechanisms of Memory Formation: Concepts of Long-term Potentiation and Beyond - Hardcover

Hardcover

ISBN 10: 052177067X ISBN 13: 9780521770675

Publisher: Cambridge University Press, 2000

Synopsis

Long-term potentiation (LTP) is by far the most dominant model for neuronal changes that might encode memory. LTP is an elegant concept that meets many criteria set up by theoreticians long before the model's discovery, and it also fits anatomical data of learning-dependent synapse changes. Since the discovery of LTP, the question has remained about how closely LTP produced in vitro by artificial stimulation of neurons actually models putative learning-induced synaptic changes. A number of recent investigations have tried to correlate synaptic changes observed after learning with changes produced by artificial stimulation of neurons. These studies have failed to find a correlation between the two forms of synaptic plasticity. In this book, an international group of neurobiologists and psychologists discuss their latest ideas and data. The results of experiments using electrophysiological techniques in vitro are discussed and compared with the results of in vivo experiments. Learning experiments are also discussed. Theoretical models such as the Hebb theory of synaptic changes during learning are compared to different models that do not predict upregulation of synaptic transmission. A wide approach is taken, and research and models in different brain areas such as the neocortex and the basal brain are discussed.

About this title

Review

"...this volume can be recommended for those who wish to succinctly survey the current state of science... This book offers a timely collection of well-written articles..." Timothy J. Teyler, Quarterly Review of Biology

Book Description

In this book, an international group of neurobiologists and psychologists discuss their latest findings and data which both support and challenge the long-term potentiation (LTP) model that suggests learning induces changes in communications between neurons. Essential reading for researchers and graduate students working in neuroscience, psychology and physiology.

Edition details

• Publisher: Cambridge University Press
• Publication date: 2000
• Language: English
• ISBN 10: 052177067X
• ISBN 13: 9780521770675
• Binding: Hardcover
• Number of pages: 528
• Editor: Hölscher Christian