Optimal High-Throughput Screening: Practical Experimental Design and Data Analysis for Genome-Scale RNAi Research - Hardcover

Zhang, Xiaohua Douglas

 
9780521517713: Optimal High-Throughput Screening: Practical Experimental Design and Data Analysis for Genome-Scale RNAi Research
Hardcover
ISBN 10: 0521517710 ISBN 13: 9780521517713
Publisher: Cambridge University Press, 2011

Synopsis

This concise, self-contained and cohesive book focuses on commonly used and recently developed methods for designing and analyzing high-throughput screening (HTS) experiments from a statistically sound basis. Combining ideas from biology, computing and statistics, the author explains experimental designs and analytic methods that are amenable to rigorous analysis and interpretation of RNAi HTS experiments. The opening chapters are carefully presented to be accessible both to biologists with training only in basic statistics and to computational scientists and statisticians with basic biological knowledge. Biologists will see how new experiment designs and rudimentary data-handling strategies for RNAi HTS experiments can improve their results, whereas analysts will learn how to apply recently developed statistical methods to interpret HTS experiments.

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About the Author

Dr Xiaohua Douglas Zhang is an associate director at Merck Research Laboratories. He has worked on data analysis for genome-wide RNAi research and microarrays in drug discovery and development for various diseases for many years. He has continuously developed novel analytic methods and experimental designs for quality control and hit selection in genome-scale RNAi research. He and his colleagues have published many papers in various peer-reviewed journals, including Cell Host and Microbe, Nucleic Acids Research, Bioinformatics, Genetic Epidemiology, the Journal of Biological Chemistry, Pharmacogenomics, Genomics and the Journal of Biomolecular Screening, among many others.

"About this title" may belong to another edition of this title.

Publisher
Cambridge University Press
Publication date
2011
Language
English
ISBN 10 
0521517710
ISBN 13 
9780521517713
Binding
Hardcover
Edition number
1
Number of pages
232

Other Popular Editions of the Same Title

9780521734448: Optimal High-Throughput Screening: Practical Experimental Design and Data Analysis for Genome-Scale RNAi Research

Featured Edition

ISBN 10:  0521734444 ISBN 13:  9780521734448
Publisher: Cambridge University Press, 2011
Softcover