Modulation of MHC Antigen Expression and Disease - Hardcover

Hardcover

ISBN 10: 0521495784 ISBN 13: 9780521495783

Publisher: Cambridge University Press, 1995

Synopsis

The major histocompatibility complex (MHC) genes are involved in the immune system's response to tumour and infected cells and in generating an immune response. This book brings together basic aspects of the regulation of MHC antigens with important clinical applications (in viral infection, viral oncology, cancer biology and autoimmunity). There is a strong emphasis on situations where MHC expression is modulated (either stimulated or repressed). The book's major themes are: the mechanisms of MHC expression explored at several levels including the transcription and translation of MHC genes and the insertion of MHC protein molecules into plasma membranes; the effect of cytokines on MHC expression both in the aetiology of certain diseases and in possible immunotherapeutic approaches to disease; and the use of gene therapy to modify MHC expression in cancer cells, and thereby cause tumour rejection.

About this title

Review

'This book is a superb summary of current understanding by some of the leading investigators.' David R. Johnson, BMJ

'... an excellent book which all immunologists should not only read but also buy, because of all the important information collected therein.' R. Wegmann, Cellular and Molecular Biology

'... for individuals interested in MHC biology in health and in disease, this book provides a timely and up-to-date review.' Alice Gottlieb, The Lancet

'... this book can be recommended as an excellent starting point for anyone who wishes to explore the field of MHC expression.' Stephen H. Powis, Immunology Today

' ... valuable.' SGM Quarterly

'... an indispensable reference for researchers and students in cell, developmental, and molecular biology and allied disciplines'. Anticancer Research

Book Description

The major histocompatibility complex (MHC) genes are involved in the immune system response to foreign agents like viruses and tumour cells. Alteration of MHC gene expression has profound effects in certain diseases. This book brings together basic aspects of the regulation of MHC antigens with important clinical applications.

Edition details

• Publisher: Cambridge University Press
• Publication date: 1995
• Language: English
• ISBN 10: 0521495784
• ISBN 13: 9780521495783
• Binding: Hardcover
• Number of pages: 458
• Editor: Blair G. Eric, Pringle Craig R., Maudsley D. John