The Dynamic Bacterial Genome: 8 (Advances in Molecular and Cellular Microbiology, Series Number 8) - Softcover

Mullany, Peter

Softcover

ISBN 10: 0521129613 ISBN 13: 9780521129619

Publisher: Cambridge University Press, 2010

Synopsis

This book provides an in-depth analysis of the mechanisms and biological consequences of genome rearrangements in bacteria. Genome rearrangements are a result of the actions of discrete genetic elements such as conjugative transposons, plasmids, phage, and non-conjugative transposons. Bacteria also contain systems to mediate genetic rearrangements such as the general recombination pathway and specialized endogenous recombination mechanisms. The biological effects of these rearrangements are far-reaching and impact on bacterial virulence, antibiotic resistance and the ability of bacteria to avoid the attentions of the host immune system (e.g. antigenic variation). These rearrangements also provide the raw material on which natural selection can act. Each chapter examines the mechanisms involved in genome rearrangements and the direct biological consequences of these events. This book is written by leading research workers and is an invaluable resource for graduate students and researchers in this field.

About this title

About the Author

Peter Mullany is a Reader in Molecular Microbiology at University College London. His main research interests are the molecular biology and molecular ecology of conjugative transposons. He has been at the forefront of this work for the past 10 years and has pioneered the genetic analysis of the important human pathogen Clostridium difficile.

Edition details

• Publisher: Cambridge University Press
• Publication date: 2010
• Language: English
• ISBN 10: 0521129613
• ISBN 13: 9780521129619
• Binding: Paperback
• Edition number: 1
• Number of pages: 444