Items related to Drug Resistance in Cancer: Mechanisms and Models

Drug Resistance in Cancer: Mechanisms and Models - Softcover

Goldie, James

 
9780521111706: Drug Resistance in Cancer: Mechanisms and Models
Softcover
ISBN 10: 0521111706 ISBN 13: 9780521111706
Publisher: Cambridge University Press, 2009

Synopsis

Drug resistance in cancer, whereby a proportion of cancer cells evades chemotherapy, poses a profound and continuing challenge for the effective treatment of cancer. The principles underlying the biological mechanisms behind this phenomenon are clearly understood and explained in this volume. However, a deeper understanding of drug resistance requires a quantitative appreciation of the dynamic forces that shape tumour growth, including spontaneous mutation and selection processes. The authors seek to explain and to simplify these complex mechanisms, and to place them in a clinical context. Clearly explained mathematical models are used to illustrate the biological principles and provide an insight into tumour development and the effectiveness and limitations of drug treatment. It is suitable for those with a non-mathematical background and aims to enhance the effectiveness of cancer therapy.

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Review

'However, this volume provides a very good overview of the drug resistance field with special emphasis on mathematical models and can be recommended to everyone interested in the field. Even those who see math as an alien subject will find this book useful, since the mathematical portions of the text have been kept as straightforward as possible. The book is a good source of references and suggestions for further reading and should interest a wide readership including clinicians, molecular biologists, and researchers interested in tumor growth, tumor killing and mutation models.' V. Spataro, Annals of Oncology

'... required reading for all trainees in oncology.' Paul P. Carbone, Oncology

Book Description

This book provides an accessible yet sophisticated account of the mechanisms responsible for drug resistance in cancer. In addition, the authors use clearly explained mathematical models to provide an insight into tumour development and the effectiveness and limitations of drug treatment.

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Publisher
Cambridge University Press
Publication date
2009
Language
English
ISBN 10 
0521111706
ISBN 13 
9780521111706
Binding
Paperback
Edition number
1
Number of pages
256