Variation in the Human Genome: No.197 (Novartis Foundation Symposia) - Hardcover

Hardcover

ISBN 10: 0471961523 ISBN 13: 9780471961529

Publisher: Wiley–Blackwell, 1996

Synopsis

The mapping of human genes is proceeding rapidly, and genes associated with specific inherited diseases are being identified, often providing insight into the molecular cause of the disease. At the moment, however, little consideration is being given to the variation present in different human populations. This variation bears a record of the population history of our species and how this has been affected by diseases, ecological adaptations, and pharmacological and nutritional responses. Treatment of inherited diseases that involve several genes will require knowledge of the degree and nature of genetic variation present in a population. This book discusses methods of analysing population genetic data and how contemporary genetic heterogeneity arises during the evolution and migration of human populations. Specific disorders - such as cystic fibrosis, beta-thalassaemia, fragile X, phenylketonuria and tumour development susceptibility - are used to illustrate this genetic variability and mechanisms of gene mutation and evolution.

About this title

From the Back Cover

The mapping of human genes is proceeding rapidly, and genes associated with specific inherited diseases are being identified, often providing insight into the molecular cause of the disease. At the moment, however, little consideration is being given to the variation present in different human populations. This variation bears a record of the population history of our species and how this has been affected by diseases, ecological adaptations, and pharmacological and nutritional responses. Treatment of inherited diseases that involve several genes will require knowledge of the degree and nature of genetic variation present in a population. This book discusses methods of analysing population genetic data and how contemporary genetic heterogeneity arises during the evolution and migration of human populations. Specific disorders ? such as cystic fibrosis, ß-thalassaemia, fragile X, phenylketonuria and tumour development susceptibility ? are used to illustrate this genetic variability and mechanisms of gene mutation and evolution.

Edition details

• Publisher: Wiley–Blackwell
• Publication date: 1996
• Language: English
• ISBN 10: 0471961523
• ISBN 13: 9780471961529
• Binding: Hardcover
• Number of pages: 340
• Editor: Chadwick Derek J., Cardew Gail