Iron and Infection: Molecular, Physiological and Clinical Aspects - Hardcover

9780471911685: Iron and Infection: Molecular, Physiological and Clinical Aspects

Hardcover

ISBN 10: 0471911682 ISBN 13: 9780471911685

Publisher: Wiley–Blackwell, 1987

Interest in the relationship between iron and infection has increased enormously in recent years and the topic has become a very active area of research. Although several short review articles have appeared in the literature, up to now, there has been no comprehensive book giving an integrated account of the role of iron in microbial pathogenicity and in clinical infection. This book presents the most relevant new advances in the biochemistry, microbiology, molecular genetics and clinical science of the subject in depth, and highlights the gaps in our knowledge. The work encompasses bacterial, fungal and protozoal pathogens and also discusses recent discoveries which show the importance of iron uptake mechanisms to malignant and other rapidly proliferating cells. The significance of recent developments for the design and use of new vaccines and for therapeutic measures used in treating infections are also considered. The book will thus be of interest to medical microbiologists interested in infectious diseases, immunologists, microbial geneticists, haematologists and biochemists.

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From the Back Cover

Second Edition Iron and Infection Molecular, Physiological and Clinical Aspects Edited by J J Bullen University of Miami School of Medicine, USA, and E Griffiths World Health Organization, Geneva, Switzerland This revised edition covers major new advances made during the past decade on the role of iron in infection. These issues are of fundamental importance for understanding bacterial pathogenesis and resistance to infection, and are particularly relevant to present day circumstances in view of the progressive failure of antibiotics to control clinical infections. Topics covered are:
∗ Iron in biological systems
∗ Iron proteins
∗ The iron uptake systems of pathogenic organisms
∗ Iron as a regulatory signal
∗ Molecular genetics of iron transport as a component of virulence
∗ Iron and the immune system
∗ Iron binding proteins and host defence
∗ Clinical and physiological aspects
∗ Future prospects
Sepsis is a global problem which requires urgent investigation, and this second edition of Iron and Infection will be essential reading for clinical microbiologists and infectious disease specialists.

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