Structural Bioinformatics (Methods of Biochemical Analysis) - Hardcover

Hardcover

ISBN 10: 0471202002 ISBN 13: 9780471202004

Publisher: Wiley–Blackwell, 2003

Synopsis

From the Foreword: "[A] must read for all of us committed to understanding the interplay of structure and function...[T]he individual chapters outline the suite of major basic life science questions, such as the status of efforts to predict protein structure and how proteins carry out cellular functions, and also the applied life science questions such as how structural bioinformatics can improve health care through accelerating drug discovery." This book provides a basic understanding of the theories, associated algorithms, resources, and tools used in structural bioinformatics. The reader emerges with the ability to make effective use of protein, DNA, RNA, carbohydrate, and complex structures to better understand biological function. Moreover, it draws a clear connection between structural studies and the rational design of new therapies.

About this title

Review

"...a collection of very up-to-date reviews on special topics...bioinformatics specialists...will derive new inspiration from it..." -- Angewandte Chemie, Vol 42(41), 2003

From the Back Cover

"This collection . . . is a must-read for all of us committed to understanding the interplay of structure and function . . . [T]he individual chapters outline the suite of major basic life science questions such as the status of efforts to predict protein structure and how proteins carry out cellular functions, and also the applied life science questions such as how structural bioinformatics can improve health care through accelerating drug discovery."

-From the Foreword by John C. Wooley

As genomic and post-genomic innovations revolutionize the biological sciences, three-dimensional structural data continues to prove of vital importance to understanding function. Structural Bioinformatics represents an unprecedented, comprehensive account of the state of the discipline, providing an essential resource for students and practitioners.

Philip Bourne and Helge Weissig's authoritative text delivers a basic understanding of the theories, associated algorithms, resources, and tools used in structural bioinformatics. Among other topics, the book covers:

*Fundamentals of protein structure

*X-ray crystallography

*Molecular visualization

*Structure classification of proteins (SCOP)

*Class, architecture, topology, and homology (CATH) classification

*Proteins as drug targets

Practicing researchers as well as students in biology, medicine, and computer science will find Structural Bioinformatics to be this field's premier resource.

Edition details

• Publisher: Wiley–Blackwell
• Publication date: 2003
• ISBN 10: 0471202002
• ISBN 13: 9780471202004
• Binding: Hardcover
• Language: English
• Number of pages: 650
• Editor: Bourne Philip E., Weissig Helge