Cancer Risk Assessment: Chemical Carcinogenesis, Hazard Evaluation, and Risk Quantification - Hardcover

Hardcover

ISBN 10: 0470238224 ISBN 13: 9780470238226

Publisher: Wiley, 2010

Synopsis

With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and separating relevant information from erroneous.

About this title

About the Author

CHING-HUNG HSU, PhD, DABT, is a Vice President at TaiGen Biotechnology Co., Ltd. His professional experience includes positions at Merck & Co., Inc., the U.S. Environmental Protection Agency, and the California Environmental Protection Agency. Dr. Hsu earned his BS from the National Taiwan University and PhD from the Massachusetts Institute of Technology. He completed his postdoctoral training at the University of California at Berkeley. Dr. Hsu is board-certified in toxicology by the American Board of Toxicology. He has published numerous professional papers, book chapters, and technical reports. Dr. Hsu serves on the Editorial Board of two international peer-reviewed journals.

TODD STEDEFORD, PhD, JD, DABT, is a Toxicology Advisor and In-house Counsel for a multinational specialty chemical manufacturer. Previously, he was a human health toxicologist with the U.S. Environmental Protection Agency and an adjunct scientist with the Polish Academy of Sciences. Dr. Stedeford is board-certified in toxicology by the American Board of Toxicology and licensed to practice law in the District of Columbia and the State of Louisiana. He has authored over eighty publications including peer-reviewed scientific articles, government health assessments, legal articles, and scientific and legal book chapters.

From the Back Cover

Learn the core concepts and step-by-step methods for assessing cancer risk

With its focus on quantitative methods and weight of the evidence, Cancer Risk Assessment enables readers to accurately assess human cancer risk from exposure to chemical agents, including solvents, metals, mixtures, and nanoparticles. Moreover, the book helps readers understand the link between cancer risk and the basic toxicology and biology of cancer.

Each chapter of this contributed work has been written by one or more leading international experts. Their contributions integrate a comprehensive review of the scientific literature with their own personal hands-on experience as well as their knowledge of current regulations and testing guidelines. With the authors' guidance, readers can better analyze toxicological data in order to reduce the uncertainties in chemical-related cancer evaluations and risk assessments.

The book begins with an overview of cancer risk assessment, science policy, and the regulatory framework for industrial chemicals and biocides. Next, all the core concepts, skills, and methods needed to perform cancer risk assessments are covered in detail, including:

• Key fundamentals in cancer biology, chemical carcinogenesis, hormesis, and experimental evidence of thresholds for genotoxic carcinogens
• Testing guidelines and regulations for in vitro and in vivo genotoxicity testing
• Evaluation of toxicological data and its relevance to hazard evaluation and cancer risk estimation
• Methods for quantifying cancer risk, including quantitative structure-activity relationships, physiologically-based pharmacokinetic modeling, "-omics," and computational toxicology

Readers of Cancer Risk Assessment not only learn to perform state-of-the-science cancer risk assessments, but also gain valuable skills and knowledge in the more general fields of toxicology and risk assessment.

With its focus on quantitative methods and weight of the evidence, Cancer Risk Assessment enables readers to accurately assess human cancer risk from exposure to chemical agents, including solvents, metals, mixtures, and nanoparticles. Moreover, the book helps readers understand the link between cancer risk and the basic toxicology and biology of cancer.

Each chapter of this contributed work has been written by one or more leading international experts. Their contributions integrate a comprehensive review of the scientific literature with their own personal hands-on experience as well as their knowledge of current regulations and testing guidelines. With the authors' guidance, readers can better analyze toxicological data in order to reduce the uncertainties in chemical-related cancer evaluations and risk assessments.

The book begins with an overview of cancer risk assessment, science policy, and the regulatory framework for industrial chemicals and biocides. Next, all the core concepts, skills, and methods needed to perform cancer risk assessments are covered in detail, including:

• Key fundamentals in cancer biology, chemical carcinogenesis, hormesis, and experimental evidence of thresholds for genotoxic carcinogens
• Testing guidelines and regulations for in vitro and in vivo genotoxicity testing
• Evaluation of toxicological data and its relevance to hazard evaluation and cancer risk estimation
• Methods for quantifying cancer risk, including quantitative structure-activity relationships, physiologically-based pharmacokinetic modeling, "-omics," and computational toxicology

Readers of Cancer Risk Assessment not only learn to perform state-of-the-science cancer risk assessments, but also gain valuable skills and knowledge in the more general fields of toxicology and risk assessment.

Edition details

• Publisher: Wiley
• Publication date: 2010
• Language: English
• ISBN 10: 0470238224
• ISBN 13: 9780470238226
• Binding: Hardcover
• Edition number: 1
• Number of pages: 856
• Editor: Hsu Ching-Hung, Stedeford Todd