HIV-1 Integrase: Mechanism and Inhibitor Design (Wiley Series in Drug Discovery and Development)

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9780470184745: HIV-1 Integrase: Mechanism and Inhibitor Design (Wiley Series in Drug Discovery and Development)
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This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery. Despite numerous review articles and isolated book chapters dealing with HIV-1 integrase, there has not been a single source for those working to devise anti-AIDS drugs against this promising target. But this book fills that gap and offers a valuable introduction to the field for the interdisciplinary scientists who will need to work together to design drugs that target HIV-1 integrase.

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Review:

"This book will be certainly a valuable reference source for all those who are interested in antiviral drug discovery. All of the information contained in this text offers a rich scientific support for researchers in academia and industry at any level who are interested in enhancing their knowledge on a very fascinating scientific topic." (ChemMedChem, 2012)

From the Back Cover:

Provides the Foundation Needed to Design Effective HIV-1 Integrase Inhibitors

Around the world, scientists have been working for years with the goal of designing effective HIV-1 integrase inhibitors in the battle against AIDS. This book reviews all their latest research findings on both inhibitor design and the mechanisms of action of HIV-1 integrase. Chapters have been contributed by leading pioneers in the field from North America, Europe, and Asia. These contributions represent not only a thorough review of the current literature, but also the authors' firsthand experience in drug development and design. Coverage includes such topics as:

  • Integrase mechanism, structure, and function

  • HIV-1 integrase-DNA interaction

  • Host factors affecting provirus stability and silencing

  • Role of metals in HIV-1 integrase inhibitor design

  • Historic perspectives, challenges, and future opportunities

As the first publication to comprehensively examine HIV-1 integrase, this book is essential reading for anyone involved in inhibitor drug discovery.

  • Integrates chemical, biochemical, and biological approaches, enabling readers to take full advantage of a promising target enzyme for combating HIV and retroviruses

  • Illustrates rational drug design for a complex drug target with plenty of step-by-step examples

  • Addresses drug design issues from a variety of perspectives to help readers understand both the challenges and opportunities of developing a successful HIV-1 integrase inhibitor

This book fills an important gap in the review literature, offering a valuable introduction to the field for scientists who need to collaborate with researchers in several disciplines in order to design drugs that effectively target HIV-1 integrase.

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