HIV-1 Integrase: Mechanism and Inhibitor Design (Wiley Series in Drug Discovery and Development)

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9780470184745: HIV-1 Integrase: Mechanism and Inhibitor Design (Wiley Series in Drug Discovery and Development)
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This book comprehensively covers the mechanisms of action and inhibitor design for HIV–1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery. Despite numerous review articles and isolated book chapters dealing with HIV–1 integrase, there has not been a single source for those working to devise anti–AIDS drugs against this promising target. But this book fills that gap and offers a valuable introduction to the field for the interdisciplinary scientists who will need to work together to design drugs that target HIV–1 integrase.

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Review:

This book will be certainly a valuable reference source for all those who are interested in antiviral drug discovery. All of the information contained in this text offers a rich scientific support for researchers in academia and industry at any level who are interested in enhancing their knowledge on a very fascinating scientific topic.   (ChemMedChem, 2012)

 

From the Back Cover:

Provides the Foundation Needed to Design Effective HIV–1 Integrase Inhibitors

Around the world, scientists have been working for years with the goal of designing effective HIV–1 integrase inhibitors in the battle against AIDS. This book reviews all their latest research findings on both inhibitor design and the mechanisms of action of HIV–1 integrase. Chapters have been contributed by leading pioneers in the field from North America, Europe, and Asia. These contributions represent not only a thorough review of the current literature, but also the authors′ firsthand experience in drug development and design. Coverage includes such topics as:

  • Integrase mechanism, structure, and function

  • HIV–1 integrase DNA interaction

  • Host factors affecting provirus stability and silencing

  • Role of metals in HIV–1 integrase inhibitor design

  • Historic perspectives, challenges, and future opportunities

As the first publication to comprehensively examine HIV–1 integrase, this book is essential reading for anyone involved in inhibitor drug discovery.

  • Integrates chemical, biochemical, and biological approaches, enabling readers to take full advantage of a promising target enzyme for combating HIV and retroviruses

  • Illustrates rational drug design for a complex drug target with plenty of step–by–step examples

  • Addresses drug design issues from a variety of perspectives to help readers understand both the challenges and opportunities of developing a successful HIV–1 integrase inhibitor

This book fills an important gap in the review literature, offering a valuable introduction to the field for scientists who need to collaborate with researchers in several disciplines in order to design drugs that effectively target HIV–1 integrase.

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Book Description John Wiley and Sons Ltd, United States, 2011. Hardback. Condition: New. New. Language: English. Brand new Book. This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery. Despite numerous review articles and isolated book chapters dealing with HIV-1 integrase, there has not been a single source for those working to devise anti-AIDS drugs against this promising target. But this book fills that gap and offers a valuable introduction to the field for the interdisciplinary scientists who will need to work together to design drugs that target HIV-1 integrase. Seller Inventory # BTE9780470184745

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Book Description John Wiley and Sons Ltd, United States, 2011. Hardback. Condition: New. New. Language: English. Brand new Book. This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery. Despite numerous review articles and isolated book chapters dealing with HIV-1 integrase, there has not been a single source for those working to devise anti-AIDS drugs against this promising target. But this book fills that gap and offers a valuable introduction to the field for the interdisciplinary scientists who will need to work together to design drugs that target HIV-1 integrase. Seller Inventory # BZV9780470184745

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