Liquid Chromatography Time-of-Flight Mass Spectrometry: Principles, Tools, and Applications for Accurate Mass Analysis: 173 (Chemical Analysis: A ... on Analytical Chemistry and Its Applications) - Hardcover

Hardcover

ISBN 10: 0470137975 ISBN 13: 9780470137970

Publisher: Wiley-Interscience, 2009

Synopsis

Time of flight mass spectrometry identifies the elements of a compound by subjecting a sample of ions to a strong electrical field. Illuminating emerging analytical techniques in high-resolution mass spectrometry, Liquid Chromatography Time-of-Flight Mass Spectrometry shows readers how to analyze unknown and emerging contaminants―such as antibiotics, steroids, analgesics―using advanced mass spectrometry techniques. The text combines theoretical discussion with concrete examples, making it suitable for analytical chemists, environmental chemists, organic chemists, medicinal chemists, university research chemists, and graduate and post-doctorate students.

About this title

About the Author

Imma Ferrer, PHD, has twelve years of hands-on experience in ion trap, triple quadrupole, and time-of-flight mass spectrometry of small molecules as applied to environmental and pharmaceutical chemistry. She is currently a Professional Research Associate of the Center for Environmental Mass Spectrometry at the University of Colorado in Boulder, Colorado. She is the author of the book Liquid Chromatography/Mass Spectrometry, MS/MS and Time-of-Flight MS: Analysis of Emerging Contaminants. She is also the author of numerous highly cited papers on the analysis of pesticides and pharmaceuticals by liquid chromatography mass spectrometry.

E. Michael Thurman, PHD, is a highly cited scientist in environmental chemistry and an Emeritus Scientist with the U.S. Geological Survey. He is currently Director of the Center for Environmental Mass Spectrometry at the University of Colorado, in Boulder, Colorado. His bibliography consists of more than 200 publications in environmental chemistry, including more than 100 journal articles, twenty proceedings and chapters, and eighty U.S. Geological Survey publications. Dr. Thurman has published five books dedicated to the chemical analysis of pesticides and natural products, sample preparation, and mass spectrometry.

From the Back Cover

The most advanced techniques for analyzing unknown and emerging contaminants

n recent years, we have witnessed an increase in mass accuracy from greater than 5 ppm to less than 1 ppm. At the same time, resolving power for benchtop time-of-flight mass instruments has increased from 2,000 5,000 to 10,000 20,000. Responding to these and other important new developments in mass spectrometry, this contributed work reviews, synthesizes, and analyzes the latest discoveries, techniques, and practical applications in accurate mass analysis. The authors are all leading experts, many of whom are pioneers in the development of time-of-flight techniques to address environmental problems.

Liquid Chromatography Time-of-Flight Mass Spectrometry is divided into three parts:

• Part One: Principles and Theoretical Aspects of Accurate Mass, sets forth the fundamentals of accurate mass by liquid chromatography/time-of-flight (LC/TOF) mass spectrometry

• Part Two: Tools for Unknown Identification Using Accurate Mass, explores the gamut of TOF tools, including exact-mass databases, isotopic mass defects, and isotopic ratios and neutral losses

• Part Three: Applications of LC/TOF-MS for the Identification of Small Molecules, examines applications across a broad range of disciplines, including pharmaceuticals, pesticides, veterinary medicine, toxicology, forensics, environmental science, and food analysis

Throughout the book, theoretical discussions are illustrated with concrete examples that show readers how to perform their own accurate analyses.

By arming chemists with the principles, tools, and applications of LC/TOF mass spectrometry, this book enables them to apply the most advanced techniques to analyze unknown and emerging contaminants with the greatest level of accuracy possible.

From the Inside Flap

The most advanced techniques for analyzing unknown and emerging contaminants

n recent years, we have witnessed an increase in mass accuracy from greater than 5 ppm to less than 1 ppm. At the same time, resolving power for benchtop time-of-flight mass instruments has increased from 2,000–5,000 to 10,000–20,000. Responding to these and other important new developments in mass spectrometry, this contributed work reviews, synthesizes, and analyzes the latest discoveries, techniques, and practical applications in accurate mass analysis. The authors are all leading experts, many of whom are pioneers in the development of time-of-flight techniques to address environmental problems.

Liquid Chromatography Time-of-Flight Mass Spectrometry is divided into three parts:

• Part One: Principles and Theoretical Aspects of Accurate Mass, sets forth the fundamentals of accurate mass by liquid chromatography/time-of-flight (LC/TOF) mass spectrometry

• Part Two: Tools for Unknown Identification Using Accurate Mass, explores the gamut of TOF tools, including exact-mass databases, isotopic mass defects, and isotopic ratios and neutral losses

• Part Three: Applications of LC/TOF-MS for the Identification of Small Molecules, examines applications across a broad range of disciplines, including pharmaceuticals, pesticides, veterinary medicine, toxicology, forensics, environmental science, and food analysis

Throughout the book, theoretical discussions are illustrated with concrete examples that show readers how to perform their own accurate analyses.

By arming chemists with the principles, tools, and applications of LC/TOF mass spectrometry, this book enables them to apply the most advanced techniques to analyze unknown and emerging contaminants with the greatest level of accuracy possible.

Edition details

• Publisher: Wiley-Interscience
• Publication date: 2009
• Language: English
• ISBN 10: 0470137975
• ISBN 13: 9780470137970
• Binding: Hardcover
• Edition number: 1
• Number of pages: 280
• Editor: Ferrer Imma, Thurman E. Michael