Gene models of schizophrenia: 179 (Progress in Brain Research): Volume 179 - Hardcover

Sawa, Akira

Hardcover

ISBN 10: 044453430X ISBN 13: 9780444534309

Publisher: Elsevier Science, 2009

Synopsis

This is a well-established international series that examines major areas of basic and clinical research within neuroscience (as well as emerging and promising subfields): neuroanatomy, neurophysiology, neuroimaging, neurobiology, neuropharmacology, neuroendocrinology, neuropathology, neuropsychiatry, and neurobehavior. This volume provides a thorough treatment of gene models of schizophrenia, presenting articles from leading contributors in this important area.

About this title

From the Back Cover

This volume focuses on how genetic models for schizophrenia, that is manipulation in genetic susceptibility factors for the disease, have potential in opening a new window of better understanding of etiology-relevant mechanisms. In addition, these models can provide a new platform for drug screening toward the treatment of the disease. The text systematically introduces the representative models for schizophrenia currently available in mice, including mice with modulation of neurotransmission (glutamate and dopamine receptors, respectively) and key intracellular signaling (Disrupted in Schizophrenia, Dysbindin, and phosphodiesterase) possibly associated with neurotransmission, together with genetic support. It also covers novel techniques to generate mouse models for schizophrenia and refers to the use of drosophila, zebrafish, and primates for modeling the disease, in addition to rodents.

Edition details

• Publisher: Elsevier Science
• Publication date: 2009
• Language: English
• ISBN 10: 044453430X
• ISBN 13: 9780444534309
• Binding: Hardcover
• Edition number: 1
• Number of pages: 250