Fundamentals of Brain Organoids for Neurological Diseases - Softcover

 
9780443298981: Fundamentals of Brain Organoids for Neurological Diseases
Softcover
ISBN 10: 044329898X ISBN 13: 9780443298981
Publisher: Academic Press, 2025

Synopsis

Researchers use brain organoids to study the formation of neural tissues, investigate the processes involved in brain development, and gain a better understanding of neurological disorders and diseases. Brain organoids are particularly useful in studying developmental disorders, neurodegenerative diseases, and infectious diseases that affect the brain. Fundamental of Brain Organoids for Neurological Diseases provides a practical resource for researchers on how to utilize and apply brain organoids. This book is organized into nine distinct sections, guiding the reader through each step from advanced overview of what organoids are to the use of brain organoids in various neurodevelopmental disorders and neurodegenerative diseases. In later sections, this book reviews the necessary methods involved in organoid development including the elements and challenges involved. This book will serve as a valuable tool for researchers, helping to advance the understanding of brain biology and disease mechanisms.

  • Presents the steps involved in the generation of brain organoids from HiPSCs onwards
  • Summarizes the importance of organoids in understanding various neurodevelopmental disorders
  • Reviews the ongoing clinical trials using brain organoids
  • Discusses ethical considerations when conducting organoid research

"synopsis" may belong to another edition of this title.

About the Authors

Dr. Balachandar Vellingiri mainly works on neurological diseases and analyzing its genetic impact. He is working on various neurological diseases to investigate the molecular mechanism and developing human induced pluripotent stem cells (HiPSCs), and generating patient-derived Brain organoids as a promising disease model for various neurological diseases because understanding the inside mechanism of neurological diseases is always a difficult task. Exploring the cutting-edge molecular, cellular, and translational neuroscience approaches, he aims to unravel disease mechanisms, identify therapeutic targets, and develop innovative interventions to slow or reverse neurological diseases. He is well-expertise in techniques such as molecular cytogenetics, pathway analysis, and techniques in developing HiPSCs and Brain organoids, especially for neurological diseases. He has published over 100 research and review articles in various Internationally reputed SCI journals, 12 Book chapters and one book on Autism Spectrum Disorder.



Dr Mahalaxmi Balachandar has experience in handling neurological disorder patients and has conducted genetic and epigenetic studies. She has experience in handling bone marrow derived mesenchymal stem cells (BM-MSCs) as a promising therapeutic agent for LHON disease. Further, Dr Mahalaxmi Balachandar has generated Brain organoids from various neurodevelopmental diseases. Her role in terms of research is to continually engage in research and update my knowledge to inspire the students to do their own original research. She has published almost 50 review and research articles in several internationally reputed SCI journals. Her articles in reputable international journals demonstrate how performing cutting edge research is made possible by updating current research technologies.

From the Back Cover

Researchers use brain organoids to study the formation of neural tissues, investigate the processes involved in brain development, and gain a better understanding of neurological disorders and diseases. Brain organoids are particularly useful in studying developmental disorders, neurodegenerative diseases, and infectious diseases that affect the brain. Fundamental of Brain Organoids for Neurological Diseases provides a practical resource for researchers on how to utilize and apply brain organoids. This book is organized into nine distinct sections, guiding the reader through each step from advanced overview of what organoids are to the use of brain organoids in various neurodevelopmental disorders and neurodegenerative diseases. In later sections, this book reviews the necessary methods involved in organoid development including the elements and challenges involved. This book will serve as a valuable tool for researchers, helping to advance the understanding of brain biology and disease mechanisms.

"About this title" may belong to another edition of this title.

Publisher
Academic Press
Publication date
2025
Language
English
ISBN 10 
044329898X
ISBN 13 
9780443298981
Binding
Paperback
Number of pages
362
Editor
Vellingiri