Modulation of Oxidative Stress: Biochemical, Physiological and Pharmacological Aspects - Softcover

9780443192470: Modulation of Oxidative Stress: Biochemical, Physiological and Pharmacological Aspects

Softcover

ISBN 10: 0443192472 ISBN 13: 9780443192470

Publisher: Academic Press, 2023

Modulation of Oxidative Stress: Biochemical, Physiological and Pharmacological Aspects explores the field using an interdisciplinary approach, including chemical, biological, physiological, pharmaceutical, pharmacological and physicochemical perspectives. The book is comprised of three main parts, with the first discussing the biochemical aspects of oxidative stress modulation. Other sections cover physiological and pathophysiological aspects on relevant conditions, including aging, neurological diseases, cerebral cavernous malformation, maternal and early-life malnutrition, Alzheimer’s disease, liver transplant, and cancer. Final content is dedicated to pharmacological aspects and includes chapters on phytotherapy and flavonoids.

This book is a strong reference for pharma researchers in academia and industry considering leveraging modulation of oxidative stress as a strategy for the development of new drugs. Biochemists and Nutritionists may also benefit of the foundational understanding of cellular redox processes laid out.

Provides the latest updates in the fast-developing field of REDOX biochemistry and pharmacology
Presents content that is clear and easy to read
Useful for researchers and instructors in many fields

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About the Authors

Prof. Luciano Saso is a Professor of Pharmacology of the Faculty of Pharmacy and Medicine of Sapienza University of Rome, Italy. He is author of more than 350 original scientific articles published in peer reviewed international journals mainly in the field of pharmacological modulation of oxidative stress (H-index Google Scholar 62). He coordinated several international research projects and has been referee for many national and international funding agencies and international scientific journals in the last 25 years and he has been Editor and Guest Editor of Special Issues of different international journals.

Prof. Alessandro Giuffr� is a Senior Researcher of the National Research Council of Italy (Consiglio Nazionale delle Ricerche - CNR). Since 2020 he is Director of the CNR Institute of Molecular Biology and Pathology (IBPM) in Rome. Since he was awarded his PhD in Biochemistry in 1997, he has investigated the molecular mechanisms underlying the metabolism of O2, nitric oxide (NO), hydrogen sulfide (H2S) and related reactive species, with the ultimate goal of elucidating the role of these molecules in human physiology and pathophysiology. His research has focused on a variety of microbial and human enzymes and their ability to metabolize O2, NO and related species, as well as on the effects of NO on cellular bioenergetics. More recently his interests have extended also to H2S, another important small gaseous molecule with a key role in cell signaling. Currently, he has signed 95 articles in peer-reviewed International journals, with more than 3.500 citations.

Dr. Valacchi has been interested in evaluating the effect of exogenous and endogenous sources of oxidative stress on target organs, such as skin, GI tract and lung, and the signal pathways involved in the cellular responses to these insults with special focus on epithelial wound healing. In addition, he aims to study how new topical approaches (derived from natural and synthetic compounds) can ameliorate wound healing and tissue regeneration in both physiological and pathological situations. In the last 10 years he has also been pursuing research involved in understanding the role of oxidative stress in a rare disease, Rett Syndrome, defined as a neurodevelopment pathology, and in the aging processes and how dietary intervention can improve the clinical feature.

Dr. Maccarrone is Professor and Chair of Biochemistry at the Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila (Italy). He is also Head of the Lipid Neurochemistry Unit at the European Center for Brain Research – IRCCS Santa Lucia Foundation, Rome. For his research activity he has received the “4th Royan International Research Award for Reproductive Biomedicine� (2003), the “2007 IACM Award for Basic Research�, the “2016 Mechoulam Award�, and the “2020 Tu Youyou Award�. Chair of the 2015 Gordon Research Conference on “Cannabinoid Function in the CNS�. Visiting Professor at Leiden University (Leiden Institute of Chemistry, The Netherlands) in 2017. Faculty member of The Lambert Center for the Study of Medicinal Cannabis and Hemp at Thomas Jefferson University in Philadelphia, since 2019. Visiting Professor at Cambridge University (Department of Psychology, U.K.) in 2019. Published more than 510 full papers, of which 60 with I.F. ≥ 9. He is listed among the Top Italian Scientists.

From the Back Cover

Reactive oxygen (ROS), nitrogen (RNS), and sulfur (RSS) species are implicated in the pathogenesis of a variety of pathological conditions, including chronic infections, inflammatory disorders, cardiovascular diseases, neurodegenerative diseases, and cancer. Modulation of Oxidative Stress: Biochemical, Physiological and Pharmacological Aspects is edited by a stellar team of active researchers. The book explores the field using an interdisciplinary approach, including chemical, biological, physiological, pharmaceutical, pharmacological, and physicochemical perspectives.

The book is comprised of three main parts. The first one discusses the biochemical aspects of oxidative stress modulation. It opens with an introduction to the field by the Editors, followed by chapter two covering antioxidants as modulators against proteinopathies, chapter three on cutaneous physiological redox, and chapter four on ferroptosis and metabolism. Part two – physiological and pathophysiological aspects include a collection of chapters on relevant conditions, including aging, neurological diseases, cerebral cavernous malformation, maternal and early-life malnutrition, Alzheimer’s disease, liver transplant, and cancer. Part three is dedicated to pharmacological aspects and includes chapters on phytotherapy, and flavonoids.

Modulation of Oxidative Stress: Biochemical, Physiological and Pharmacological Aspects is a strong reference for pharma researchers in academia and industry considering leveraging modulation of oxidative stress as a strategy for the development of new drugs. Biochemists and Nutritionists may also benefit of the foundational understanding of cellular redox processes laid out.

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