Enzymes and Their Inhibitors: Drug Development (CRC Enzyme Inhibitors) - Hardcover

Hardcover

ISBN 10: 0415334020 ISBN 13: 9780415334020

Publisher: CRC Press, 2004

Synopsis

Focusing on the development of enzyme inhibitors as therapeutic drugs, Enzymes and Their Inhibitors: Drug Development provides a concise overview of the chemistry of major types of enzymes and their inhibitors. The opening chapters introduce readers to the structure, functions, mechanisms, and kinetics of enzymes, including their use as disease markers, analytical reagents, and in industrial processes. Subsequent chapters discuss the different types of enzyme inhibitors and the principles involved in developing them into effective drugs. This outstanding text, also valuable as a professional reference, will be useful to all students of pharmacology and medicinal chemistry.

About this title

Synopsis:

In recent years the number of new drugs described as enzyme inhibitors has increased significantly. Once an enzyme target is selected or discovered for a particular disease or infection, detailed information must be compiled for the rational design of an inhibitor. Until now, a single handbook containing that crucial background information has not been available. Covering everything you need to know about this complex subject, "Enzymes and Their Inhibition" examines enzyme inhibition in detail, and describes the design and development of such inhibitors. Focusing on the development of enzyme inhibitors as therapeutic drugs, "Enzymes and Their Inhibition" provides an overview of the chemistry of major types of enzymes and their inhibitors. The opening chapters introduce readers to the structure, substrates, kinetics, and mechanisms of enzymes. Subsequent chapters discuss various types of enzyme inhibitors and the principles involved in developing them into effective drugs. "Enzymes and Their Inhibition" describes the problems that can be encountered in translating results from the bench to the market place, and suggests approaches that circumvent these difficulties.

This outstanding text for students in pharmacology and medicinal chemistry is also a valuable professional reference.

About the Author:

H. John Smith, Claire Simons

About this edition

• Publisher: CRC Press
• Publication date: 2004
• ISBN 10: 0415334020
• ISBN 13: 9780415334020
• Binding: Hardcover
• Edition number: 1
• Number of pages: 328
• Editor: Smith H. John, Simons Claire