The Third Edition of this classic text has been completely revised and updated and greatly expanded in scope. With three new associate editors and over 20 new chapters, the book provides comprehensive coverage of the inflammatory process, its clinical manifestations, and its pharmacologic modulation. This edition includes vital new information on cytokines and cytokine receptors, signal transduction, mechanisms of cellular adhesion, angiogenesis, and wound healing. The "Clinical Correlates" section features new chapters on autoantibodies, sepsis and septic shock, reperfusion injury, type 1 diabetes, inflammation and cancer, cancer immunology, and induction of inflammation by Helicobacter pylori. The section on therapeutic modulation of inflammation includes new chapters on complement inhibitors, cytokine inhibitors, agents targeting transcription factors, and emerging technologies for the discovery of small-molecule therapeutics. Other new chapters in this section cover second line antirheumatic drugs, tolerance to anti-inflammatory drugs, immunomodulation by intravenous gammaglobulin, and antimicrobial peptides
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New England Journal of Medicine -- Praise for the Second Edition (1992):|"It is an enormous undertaking to put together a textbook dealing with a subject as vast and diverse as inflammation. This task has been completed in impressive fashion in a book that will become the predominant reference in its field...There is no doubt that this book will be a valuable reference for students, fellows, clinicians, and basic scientists interested in inflammation."--New England Journal of Medicine
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