Analyzing Longitudinal Clinical Trial Data: A Practical Guide (Chapman & Hall/CRC Biostatistics Series) - Softcover

Mallinckrodt, Craig; Lipkovich, Ilya

Softcover

ISBN 10: 0367736586 ISBN 13: 9780367736583

Publisher: Chapman and Hall/CRC, 2020

Synopsis

Analyzing Longitudinal Clinical Trial Data: A Practical Guide provides practical and easy to implement approaches for bringing the latest theory on analysis of longitudinal clinical trial data into routine practice.The book, with its example-oriented approach that includes numerous SAS and R code fragments, is an essential resource for statisticians and graduate students specializing in medical research.

The authors provide clear descriptions of the relevant statistical theory and illustrate practical considerations for modeling longitudinal data. Topics covered include choice of endpoint and statistical test; modeling means and the correlations between repeated measurements; accounting for covariates; modeling categorical data; model verification; methods for incomplete (missing) data that includes the latest developments in sensitivity analyses, along with approaches for and issues in choosing estimands; and means for preventing missing data. Each chapter stands alone in its coverage of a topic. The concluding chapters provide detailed advice on how to integrate these independent topics into an over-arching study development process and statistical analysis plan.

About this title

About the Author

Craig Mallinckrodt and Ilya Lipkovich each have extensive experience in medical research and longitudinal analyses. Dr. Mallinckrodt is a Research Fellow at Eli Lilly and Company and a Fellow of the American Statistical Association. He has won numerous awards, including the 2014 award for statistical excellence in the Pharmaceutical Industry from the Royal Statistical Society and PSI (Statisticians in the Pharmaceutical Industry). Dr. Lipkovich is a Principal Scientific Advisor at Quintiles. He is a widely-published author and frequent presenter at conferences and has developed a number of successful short courses and tutorials.

From the Back Cover

Missing data in longitudinal clinical trials has justifiably been the target of considerable research. However, missing data is just one of the many considerations in the analysis of longitudinal data, and focus on the data we don't have should not distract from focus on the data we do have. The statistical theory relevant to analyses of longitu

Edition details

• Publisher: Chapman and Hall/CRC
• Publication date: 2020
• Language: English
• ISBN 10: 0367736586
• ISBN 13: 9780367736583
• Binding: Paperback
• Edition number: 1
• Number of pages: 332