Absolute Risk: Methods and Applications in Clinical Management and Public Health (Chapman & Hall/CRC Monographs on Statistics and Applied Probability) - Softcover

Pfeiffer, Ruth M.; Gail, Mitchell H.

Softcover

ISBN 10: 0367657813 ISBN 13: 9780367657819

Publisher: Chapman and Hall/CRC, 2020

Synopsis

Absolute Risk: Methods and Applications in Clinical Management and Public Health provides theory and examples to demonstrate the importance of absolute risk in counseling patients, devising public health strategies, and clinical management. The book provides sufficient technical detail to allow statisticians, epidemiologists, and clinicians to build, test, and apply models of absolute risk.

Features:

• Provides theoretical basis for modeling absolute risk, including competing risks and cause-specific and cumulative incidence regression





• Discusses various sampling designs for estimating absolute risk and criteria to evaluate models





• Provides details on statistical inference for the various sampling designs





• Discusses criteria for evaluating risk models and comparing risk models, including both general criteria and problem-specific expected losses in well-defined clinical and public health applications





• Describes many applications encompassing both disease prevention and prognosis, and ranging from counseling individual patients, to clinical decision making, to assessing the impact of risk-based public health strategies





• Discusses model updating, family-based designs, dynamic projections, and other topics

Ruth M. Pfeiffer is a mathematical statistician and Fellow of the American Statistical Association, with interests in risk modeling, dimension reduction, and applications in epidemiology. She developed absolute risk models for breast cancer, colon cancer, melanoma, and second primary thyroid cancer following a childhood cancer diagnosis.

Mitchell H. Gail developed the widely used "Gail model" for projecting the absolute risk of invasive breast cancer. He is a medical statistician with interests in statistical methods and applications in epidemiology and molecular medicine. He is a member of the National Academy of Medicine and former President of the American Statistical Association.

Both are Senior Investigators in the Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health.

About this title

About the Author

Ruth M. Pfeiffer is a mathematical statistician and Fellow of the American Statistical Association, with interests in risk modeling, dimension reduction, and applications in epidemiology. She developed absolute risk models for breast cancer, colon cancer, melanoma, and second primary thyroid cancer following a childhood cancer diagnosis.

Mitchell H. Gail developed the widely used "Gail model" for projecting the absolute risk of invasive breast cancer. He is a medical statistician with interests in statistical methods and applications in epidemiology and molecular medicine. He is a member of the National Academy of Medicine and former President of the American Statistical Association.

Both are Senior Investigators in the Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health.

From the Back Cover

This book addresses the development, evaluation, and application of models of absolute risk- the probability of developing a specific disease over a specified time interval in the presence of competing causes of mortality. It discusses the development of appropriate statistical methods for estimating and applying absolute risk.

Edition details

• Publisher: Chapman and Hall/CRC
• Publication date: 2020
• Language: English
• ISBN 10: 0367657813
• ISBN 13: 9780367657819
• Binding: Paperback
• Edition number: 1
• Number of pages: 201