The Fovea: Structure, Function, Development, and Tractional Disorders - Softcover

Bringmann, Andreas; Wiedemann, Peter

Softcover

ISBN 10: 032390467X ISBN 13: 9780323904674

Publisher: Academic Press, 2021

Synopsis

The Fovea: Structure, Function, Development, and Disease summarizes the current biological knowledge regarding the two types of the vertebrate fovea (and its main structural elements, the Müller cells). This information is then used to explain different aspects of human vision, foveal development, and macular disorders. Sections give an overview of the retinal structure and the different types of retinal glia, survey the structure and function of the primate and non-mammalian fovea types, discuss foveal development—with a focus on the human fovea, cover the roles of Müller cells and astrocytes in the pathogenesis and regeneration of various human macular disorders are described.

Using a translational approach, this reference is a valuable text for scientists, clinicians and physicians interested in the fovea. Readers will gain a new understanding of the cellular basics of the fovea, which is the most important part of the eye.

• Adopts a translational approach, summarizing the biological knowledge regarding the structure and function of the fovea, the roles of Müller cells in mediating the structural integrity, and function of the fovea
• Provides overviews of both basic types of the vertebrate fovea, countering the popular belief that there is only one type of the vertebrate fovea, the human fovea
• Thoroughly shows the mechanisms involved in the development of the fovea that explain the rapid improvement of visual acuity in newborns
• Explains pathological changes in the foveal structure and function with evaluation pointing toward possible prevention and/or cure

About this title

About the Authors

Since 1996, the research focus of Dr. Andreas Bringmann has been the Müller cell and the retina. He studied Biology (Animal Physiology) and worked in the basic sciences after the study. He was from 1990 to 2002 scientific assistant at the Department of Neurophysiology, Paul Flechsig Institute of Brain Research, Medical Faculty of the University of Leipzig (Head of the Department: Andreas Reichenbach, MD). Since 2002, he is the Head of the Research Laboratory of the Department of Ophthalmology and Eye Clinic, Medical Faculty of the University of Leipzig, Leipzig, Germany. He has published 181 peer-reviewed original papers, 30 review articles, 10 book chapters, and 2 books.

Dr. Peter Wiedemann is Professor of Ophthalmology at Leipzig University. He is a vitreoretinal specialist whose expertise includes complex vitreoretinal surgery and macular disorders.

Dr. Wiedemann earned his medical degree at Erlangen University, Germany. He started ophthalmic research at the Doheny Eye Institute, Los Angeles, with Dr. Stephen Ryan and completed residency and fellowship in ophthalmology at Cologne University with Prof. Klaus Heimann. In his research Dr. Wiedemann studies retinal and macular disorders and Müller cells pathophysiology.

He has authored over 500 peer reviewed publications in ophthalmology and is co-editor of the textbook Ryan´s Retina. He is a member of the German National Academy of Sciences Leopoldina, the German Ophthalmological Society, the American Academy of Ophthalmology and the Club Jules Gonin. He is also a Fellow of the Academia Ophthalmologica Internationalis (AOI), the European Academy of Ophthalmology, and a Board Member of the International Council of Ophthalmology (ICO).

From the Back Cover

The fovea as the retinal site of the sharpest vision is a pitted invagination at the inner surface of thick retinal areas which contain high photoreceptor and neuron numbers. There are two basic types of the vertebrate fovea: the fovea of non-mammalian species, which does not contain a foveola, and the primate (including human) fovea with a central foveola surrounded by sloping foveal walls. The different morphologies of both fovea types are associated with different optical properties and are suggested to mainly result from the absence and presence of retinal astrocytes.

The Fovea: Structure, Function, Development, and Disease summarizes the current biological knowledge regarding the two types of the vertebrate fovea (and its main structural elements, the Müller cells); this information is then used to explain different aspects of human vision, foveal development, and macular disorders. In the first quarter the book gives an overview of the retinal structure and the different types of retinal glia, in the second quarter it surveys the structure and function of the primate and non-mammalian fovea types, and then it discusses the foveal development with a focus on the human fovea. In the last part, the roles of Müller cells and astrocytes in the pathogenesis and regeneration of various human macular disorders are described.

Using a translational approach, this reference is a valuable text for scientists, clinicians, and physicians interested in the fovea. Readers can expect to understand the cellular basics of the fovea, which is the most important part of the eye.

Edition details

• Publisher: Academic Press
• Publication date: 2021
• Language: English
• ISBN 10: 032390467X
• ISBN 13: 9780323904674
• Binding: Paperback
• Number of pages: 290