Cardiovascular Toxicity and Therapeutic Modalities Targeting Cardio-oncology: From Basic Research to Advanced Study - Softcover

Softcover

ISBN 10: 0323904610 ISBN 13: 9780323904612

Publisher: Academic Press, 2022

Synopsis

Cardiovascular Toxicity and Therapeutic Modalities Targeting Cardio-Oncology: From Basic Research to Advanced Study analyzes the emerging the field of cardio-oncology, reviewing recent advancements in the field, discussing how to monitor and treat cancer survivors for cardiotoxicity, and identifying potential cardiac side effects in novel cancer therapies. By adopting a translational approach, the book first comprehensively covers the basic science, mechanisms and concepts, which is followed by advanced state-of-art of cardio-oncology. Other sections cover tyrosine kinase inhibitors, Anthracyclines, and biomarkers in cardiotoxicity induced by chemotherapeutic drugs, noninvasive cardiovascular imaging techniques, radiotherapy induced cardiovascular, and more.

Anti-cancer treatment is associated with serious cardiovascular adverse events, including arterial and pulmonary hypertension, supraventricular and ventricular arrhythmias, systolic and diastolic cardiac dysfunction and coronary artery disease. Progress in cancer therapy over the past decades improved long-term survival but increased cancer therapy-related cardiotoxicity. Both traditional chemotherapeutic agents and newer therapies have demonstrated profound cardiovascular toxicities. It is important to understand the mechanisms of these toxicities to establish strategies for the prevention and management of complications―arrhythmias, heart failure, and even death.

• Adopts a translational approach and comprehensively covers the basic science, mechanisms and concepts of cardio-oncology
• Outlines the current knowledge of biomarkers in cancer therapy-related cardiotoxicity
• Provides an understanding of the mechanisms of cardiovascular toxicity of various therapies that may lead to the identification of novel targets to reduce vascular complications

About this title

About the Authors

Dr. Imteyaz Qamar is working as an assistant professor at School of biotechnology, Gautam Buddha University, Greater Noida, India. His area on interest is Stress biology, and Cancer Genetics

He earned his Ph.D. in Molecular Endocrinology from Chonnam National University, South Korea with an emphasis on gene regulation and physiological function of an androgen receptor corepressor-19kD using mice model. He has written various manuscripts, grants, progress reports, pre-IND protocols, animal protocols and published in well reputed international journals. He has also received various awards such as Brain Korea-21 Best Research presenter award 2007, Bharath Vikas award 2016, Young Scientist Award 2017 & 2019, STE meritorious award 2019 etc. He serves as a member of editorial boards of various peer reviewed journals. He is also a member of the endocrinology society, United States of America (USA).

Dr. Pawan Kumar Maurya is a biochemist and Professor in the Department of Biochemistry at the Central University of Haryana, where he also serves as Dean of Academic Affairs. He earned his MSc and PhD in Biochemistry from the University of Allahabad. His research spans oxidative stress, aging, nanomedicine, and clinical biochemistry. He has completed postdoctoral training at several institutions in Asia and Brazil. Dr. Maurya has been honored with national and international awards for his work. He is active in professional societies including the Association of Gerontology India, the Society of Neurochemistry India, and Indian Biochemists’ and Microbiologists’ associations. His scholarly output includes books, book chapters, and numerous research articles. He contributes to technical and organizing committees for national and international conferences. A dedicated educator, he specializes in biochemical diagnostics, nanomedicine, and clinical biochemistry, with a track record of editorial work with major publishers.

From the Back Cover

Anti-cancer treatment is associated with serious cardiovascular adverse events including arterial and pulmonary hypertension, supraventricular and ventricular arrhythmias, systolic and diastolic cardiac dysfunction and coronary artery disease. Progress in cancer therapy over the past decades improved long-term survival but increased cancer therapy-related cardiotoxicity. Both traditional chemotherapeutic agents and newer therapies have demonstrated profound cardiovascular toxicities. It is important to understand the mechanisms of these toxicities to establish strategies for the prevention and management of complications―arrhythmias, heart failure, and even death.

In view of the growing clinical and healthcare relevance of cancer survivors who are at an elevated risk of dying from cardiovascular diseases, Cardiovascular Toxicity and Therapeutic Modalities Targeting Cardio-Oncology: From Basic Research to Advanced Study analyses the emerging the field of cardio-oncology; reviewing the recent advancements in the field, how to monitor and treat cancer survivors for cardiotoxicity, and identifying potential cardiac side effects in novel cancer therapies. By adopting a translational approach, the book first comprehensively covers the basic science, mechanisms, and concepts, which is followed by advanced state-of-art of cardio-oncology. The book starts with a brief introduction on cancer and cardiovascular diseases in cancer patients, as well as the changes observed in the cardiovascular system; which serves to provide a deeper understanding of therapeutic approaches targeting cardio-oncology. It then looks into the pathways and inhibitors involved in cancer immunology, as well as the biochemistry of tyrosine kinase inhibitors, Anthracyclines, and biomarkers in cardiotoxicity induced by chemotherapeutic drugs. The book then concludes with clinical focused chapters, including noninvasive cardiovascular imaging techniques, radiotherapy induced cardiovascular risk, cardiovascular complication from cancer therapy, novel anticancer drugs related to cardiotoxicity, and principles of cardiovascular rehabilitation.

Written by leading researches in various disciplines, the book serves as a valuable resource to those who are new to the field, as well as various other specialized scientists, researchers, oncologists, cardiologists, physicians and ancillary staff.

Edition details

• Publisher: Academic Press
• Publication date: 2022
• Language: English
• ISBN 10: 0323904610
• ISBN 13: 9780323904612
• Binding: Paperback
• Edition number: 1
• Number of pages: 276
• Editor: Qamar, Maurya