Arrestins: Structure and Function in Vision and Beyond - Softcover

Softcover

ISBN 10: 0323857566 ISBN 13: 9780323857567

Publisher: Academic Press, 2022

Synopsis

Arrestins: Structure and Function in Vision and Beyond examines the structural basis of the function of arrestin proteins in the brain. Linking basic, translational and clinical research, this volume begins with history and basic signaling principles and then expands to the use of proteins as potential therapeutic targets. Multiple cellular activities are detailed, including activation, signaling, GPCR endocytosis, and ERK signaling, with chapters examining both visual and non-visual arrestins. Experts in their respective fields are featured throughout, making this book essential reading for anyone who wants to explore the basic science underlying these signaling proteins.

• 2023 PROSE Awards - Winner: Finalist: Biomedicine and Neuroscience: Association of American Publishers
• Links basic, translational and clinical research on arrestin and GPCR signaling proteins in the nervous system
• Features chapters on arrestins' vital signaling functions in brain health
• Includes unique sections on their use as potential therapeutic targets
• Covers both vision and non-vision arrestins
• Provides an overview for scientists new to the study of GPCRs and arrestins

About this title

About the Author

Dr. Gurevich obtained his PhD at the Shemyakin Institute of Bioorganic Chemistry, in Moscow, Russia. He performed his postdoctoral studies at Thomas Jefferson University in Philadelphia and is currently Professor of Pharmacology at Vanderbilt University. He is a Cornelius Vanderbilt Endowed Chair. He has published more than 220 papers in reputed journals and has been serving as an editorial board member of several journals. The main focus of the work in his lab is structure-function studies of arrestins, that bind almost all of >800 G protein-coupled receptors in humans and dozens of non-receptor signaling proteins. The lab is using biochemistry, biophysics, and cell biology to elucidate arrestin elements involved in the interactions with various binding partners and to construct signaling-biased arrestins specifically targeting individual receptors and signaling pathways.

From the Back Cover

Arrestins: Structure and Function in Vision and Beyond examines the structural basis of the function of arrestin proteins in the brain. Linking basic, translational, and clinical research, this volume begins with history and basic signaling principles, and expands to the use of proteins as potential therapeutic targets. Multiple cellular activities are detailed, including activation, signaling, GPCR endocytosis, and ERK signaling, with chapters examining both visual and non-visual arrestins in the brain. Experts in their respective fields feature as chapter authors providing concise, yet accessible summaries of the recent developments in GPCR and arrestin science. This book is essential reading for anyone wishing to explore the basic science underlying these signaling proteins and their importance in brain health and neuron dysfunction.

Edition details

• Publisher: Academic Press
• Publication date: 2022
• Language: English
• ISBN 10: 0323857566
• ISBN 13: 9780323857567
• Binding: Paperback
• Edition number: 1
• Number of pages: 142
• Editor: Gurevich Vsevolod V.